Document Detail


The role of vagal efferents in regulation of gastric emptying and motility in rats.
MedLine Citation:
PMID:  12353421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RESULTS: Stimulation significantly decreased amplitude of gastric contractions about 14% (52.7 +/- +/- 24.5 vs control 66.8 +/- 15.0; p < 0.05) and increased liquid gastric emptying from isotonic solution about 10% (87.35 +/- 4.75 vs control 75.31 +/- 11.24; p < 0.001), hypertonic liquid about 15% (49.05 +/- 12.16 vs control 34.1 +/- 13.68; p < 0.001) and hypotonic liquid about 7% (83.05 +/- 8.8 vs control 76.29 +/- 11.88). The frequency of gastric contractions did not change significantly in Fast Fourier Analysis of the period of stimulations and in control group. CCK concentrations were not significantly different between stimulated and control group (0.3 +/- 0.08 vs control 0.27 +/- 0.06 pmol/L). L-NAME infusion abolished completely acceleration of gastric emptying of isotonic solution (50.38 +/- 12.66 vc control 87.82 +/- 5.49; p < 0.05), hypertonic solution (32.17 +/- 15.09 vs control 51.65 +/- 10.74; p < 0.05) and hypotonic solution (60.42 +/- 12.05 vs control 82.67 +/- 8.06; p < 0.05) during electrical stimulation.
DISCUSSION: In this experiment efferent stimulation of abdominal vagal nerve release neuromediators from afferent and efferent fibers. The main regulator seems to be nitric oxide. These results indicate the effective vagal nerve stimulation affects gastric motility and emptying. It is likely that observed effects reflect integrated response with activating vago-vagal reflexes and neurohumoral factors.
Authors:
G Królczyk; D Zurowski; Ł Dobrek; J Laskiewicz; P J Thor
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia medica Cracoviensia     Volume:  42     ISSN:  0015-5616     ISO Abbreviation:  Folia Med Cracov     Publication Date:  2001  
Date Detail:
Created Date:  2002-09-30     Completed Date:  2002-11-06     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0374617     Medline TA:  Folia Med Cracov     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  141-8     Citation Subset:  IM    
Affiliation:
Katedra Patofizjologii Collegium Medicum ul. Czysta 18, 31-121 Kraków.
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MeSH Terms
Descriptor/Qualifier:
Animals
Fourier Analysis
Gastric Emptying / physiology*
Infusions, Intravenous
Male
NG-Nitroarginine Methyl Ester / administration & dosage
Rats
Rats, Wistar
Stomach / innervation*
Vagus Nerve / physiology*
Chemical
Reg. No./Substance:
50903-99-6/NG-Nitroarginine Methyl Ester

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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