| The role of vagal efferents in regulation of gastric emptying and motility in rats. | |
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MedLine Citation:
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PMID: 12353421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonpharmacologic regulation of gastrointestinal motility may become competitive to actually applied methods in the nearest future. The Aim of this study was to evaluate effect of vagal stimulation on gastric motility and emptying. Experiments were performed on 30 male Wistar rats in vivo. Electrodes (120 um O Cr/Mo Microfil Industries) were placed on right vagal trunk below diaphragm without affecting its integrity. The fistula was implanted in gastric antrum. Stimulation parameters were: 0.3 V; 0.5 Hz, impulse duration--10 msec, time stimulation--5 min. Gastric pressure (balloon, Synectics pressure transducer, Sweden) and gastric emptying (red phenol method) were measured subsequently during and between stimulations. RESULTS: Stimulation significantly decreased amplitude of gastric contractions about 14% (52.7 +/- +/- 24.5 vs control 66.8 +/- 15.0; p < 0.05) and increased liquid gastric emptying from isotonic solution about 10% (87.35 +/- 4.75 vs control 75.31 +/- 11.24; p < 0.001), hypertonic liquid about 15% (49.05 +/- 12.16 vs control 34.1 +/- 13.68; p < 0.001) and hypotonic liquid about 7% (83.05 +/- 8.8 vs control 76.29 +/- 11.88). The frequency of gastric contractions did not change significantly in Fast Fourier Analysis of the period of stimulations and in control group. CCK concentrations were not significantly different between stimulated and control group (0.3 +/- 0.08 vs control 0.27 +/- 0.06 pmol/L). L-NAME infusion abolished completely acceleration of gastric emptying of isotonic solution (50.38 +/- 12.66 vc control 87.82 +/- 5.49; p < 0.05), hypertonic solution (32.17 +/- 15.09 vs control 51.65 +/- 10.74; p < 0.05) and hypotonic solution (60.42 +/- 12.05 vs control 82.67 +/- 8.06; p < 0.05) during electrical stimulation. DISCUSSION: In this experiment efferent stimulation of abdominal vagal nerve release neuromediators from afferent and efferent fibers. The main regulator seems to be nitric oxide. These results indicate the effective vagal nerve stimulation affects gastric motility and emptying. It is likely that observed effects reflect integrated response with activating vago-vagal reflexes and neurohumoral factors. |
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Authors:
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G Królczyk; D Zurowski; Ł Dobrek; J Laskiewicz; P J Thor |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Folia medica Cracoviensia Volume: 42 ISSN: 0015-5616 ISO Abbreviation: Folia Med Cracov Publication Date: 2001 |
Date Detail:
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Created Date: 2002-09-30 Completed Date: 2002-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374617 Medline TA: Folia Med Cracov Country: Poland |
Other Details:
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Languages: eng Pagination: 141-8 Citation Subset: IM |
Affiliation:
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Katedra Patofizjologii Collegium Medicum ul. Czysta 18, 31-121 Kraków. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fourier Analysis Gastric Emptying / physiology* Infusions, Intravenous Male NG-Nitroarginine Methyl Ester / administration & dosage Rats Rats, Wistar Stomach / innervation* Vagus Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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50903-99-6/NG-Nitroarginine Methyl Ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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