| The role for the uterine insulin-like growth factor I in early embryonic loss after superovulation in the rat. | |
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MedLine Citation:
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PMID: 8566274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To examine possible roles of the insulin-like growth factor (IGF) system in increased early embryonic loss after superovulation. DESIGN: Changes in the uterine IGF system were examined in superovulated rats. Insulin-like growth factor I (IGF-I) was infused to the right uterine horns to mimic enhanced IGF-I actions after superovulation. Uterine luminal fluids were collected after IGF-I infusions and embryos were cultured with uterine luminal fluids. MAIN OUTCOME MEASURES: Steroid hormones, IGF-I, IGF binding protein (IGFBP), and IGF-I receptor levels, developmental rate, and cell numbers of embryos. RESULTS: Elevated IGF-I levels and suppressed IGFBP levels were found from days 1 to 3 of pregnancy after superovulation. Uterine luminal fluids of the IGF-I infusion and superovulation groups impaired embryo development in vitro. Anti-IGF-I antibody infusions after superovulation reversed detrimental effects of superovulation. Dialysis of uterine luminal fluids of the IGF-I infusion and superovulation groups before culture improved embryo development. CONCLUSIONS: Enhanced IGF-I actions in the uterus after superovulation may be responsible for the increase of early embryonic loss. The detrimental factor for embryo development seems a small molecule and is likely a local product of the uterus in which IGF-I actions are enhanced. |
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Authors:
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S Katagiri; Y S Moon; B H Yuen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 65 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-03-04 Completed Date: 1996-03-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 426-36 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryonic and Fetal Development* Estradiol / blood Female Fetal Death Insulin-Like Growth Factor Binding Proteins / analysis Insulin-Like Growth Factor I / analysis, physiology* Ovulation Induction* Progesterone / blood Rats Rats, Sprague-Dawley Receptor, IGF Type 1 / analysis Superovulation* Time Factors Uterus / chemistry, physiology |
| Chemical | |
Reg. No./Substance:
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0/Insulin-Like Growth Factor Binding Proteins; 50-28-2/Estradiol; 57-83-0/Progesterone; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.10.1/Receptor, IGF Type 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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