Document Detail

The role of uterine artery Doppler in predicting adverse pregnancy outcome.
MedLine Citation:
PMID:  15183134     Owner:  NLM     Status:  MEDLINE    
The complications of placental insufficiency, pre-eclampsia and fetal growth restriction (FGR) are major causes of perinatal as well as maternal morbidity and mortality. In normal pregnancy, impedance to flow in the uterine arteries decreases with gestation, and histopathological studies suggest that this is due to trophoblastic invasion of the spiral arteries and their conversion into low-resistance vessels. Failure of trophoblastic invasion is associated with complications of uteroplacental insufficiency. Several Doppler screening studies, both in the second and more recently in the first trimester of pregnancy, have demonstrated an association between increased impedance to flow in the uterine arteries and subsequent development of pre-eclampsia, FGR and perinatal death.
Aris T Papageorghiou; Christina K H Yu; Kypros H Nicolaides
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  18     ISSN:  1521-6934     ISO Abbreviation:  Best Pract Res Clin Obstet Gynaecol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-08     Completed Date:  2004-09-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  383-96     Citation Subset:  IM    
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK.
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MeSH Terms
Arteries / ultrasonography
Fetal Growth Retardation / ultrasonography
Placental Circulation*
Pre-Eclampsia / ultrasonography
Pregnancy Outcome*
Ultrasonography, Doppler
Ultrasonography, Prenatal / methods*
Uterus / blood supply*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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