Document Detail

The role of uric acid in stroke: the issue remains unresolved.
MedLine Citation:
PMID:  18617849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although in the past decade a large number of studies have been performed to identify the relationship between uric acid and stroke, the issue remains unresolved and it is not clear whether the correlation between uric acid and stroke is circumstantial or causal. REVIEW SUMMARY: Some studies have found uric acid predictive for the development of cardiovascular disease, whereas others have failed to identify uric acid as a significant and independent risk factor after controlling for other atherosclerotic risk factors. Furthermore, uric acid, a powerful endogenous antioxidant, is increased in oxidative stress situations such as stroke. Still, it remains controversial whether elevated serum uric acid is neuroprotective or injurious at the onset of acute stroke. CONCLUSIONS: Large trials are required to provide definite answers in clinical practice and to reevaluate the goals of hypouricemic treatment in subjects with increased cardiovascular risk or during an acute cardiovascular event like stroke. This review tries to keep pace with the data concerning the association between uric acid and stroke.
Hariklia V Dimitroula; Apostolos I Hatzitolios; Haralambos I Karvounis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The neurologist     Volume:  14     ISSN:  1074-7931     ISO Abbreviation:  Neurologist     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-11     Completed Date:  2008-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503763     Medline TA:  Neurologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-42     Citation Subset:  IM    
First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Greece.
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MeSH Terms
Hyperuricemia / complications*
Risk Factors
Stroke / blood*,  complications*
Uric Acid / blood*
Reg. No./Substance:
69-93-2/Uric Acid

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