Document Detail

The role of uric acid and other crystals in osteoarthritis.
MedLine Citation:
PMID:  20425024     Owner:  NLM     Status:  MEDLINE    
Clinicians have long assumed that an association exists between crystal arthropathies and the presence of osteoarthritis (OA). However, studies establishing an independent association between calcium pyrophosphate or uric acid crystal disease and OA are sparse. Even less is known about a possible pathogenic relationship. Whereas some studies suggest that the relationships between crystals and OA may not be incidental and that crystal deposition may contribute to the onset and/or acceleration of OA joint damage, other authors have challenged this assertion. In this review, we provide an overview of past and current research elucidating the role of crystal deposition, including monosodium urate, calcium pyrophosphate, and other crystals, in OA. Given the clinical frequency of gout and that agents exist to modulate serum UA levels, special attention is given to the role of monosodium urate crystals.
Johannes Nowatzky; Rennie Howard; Michael H Pillinger; Svetlana Krasnokutsky
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  12     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
Department of Medicine, Division of Rheumatology, New York University Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
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MeSH Terms
Calcium Pyrophosphate / metabolism*
Gout / metabolism
Joints / metabolism,  pathology
Osteoarthritis / etiology,  metabolism*,  pathology
Uric Acid / metabolism*
Reg. No./Substance:
10086-45-0/Calcium Pyrophosphate; 69-93-2/Uric Acid

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