| The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications. | |
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MedLine Citation:
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PMID: 21779625 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus (DM2) and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. Therefore, great efforts have been made to identify genes associated with DM2. Uncoupling protein 2 (UCP2) is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism. All these mechanisms are associated with DM2 pathogenesis and its chronic complications. Therefore, UCP2 is a candidate gene for the development of these disorders. Indeed, several studies have reported that three common polymorphisms in UCP2 gene are possibly associated with DM2 and/or obesity. Only a few studies investigated these polymorphisms in relation to chronic complications of diabetes, with inconclusive results. |
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Authors:
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Bianca Marmontel de Souza; Taís Silveira Assmann; Lúcia Maria Kliemann; Jorge Luiz Gross; Luís Henrique Canani; Daisy Crispim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arquivos brasileiros de endocrinologia e metabologia Volume: 55 ISSN: 1677-9487 ISO Abbreviation: Arq Bras Endocrinol Metabol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403437 Medline TA: Arq Bras Endocrinol Metabol Country: Brazil |
Other Details:
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Languages: eng Pagination: 239-48 Citation Subset: IM |
Affiliation:
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Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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