| The role of ubiquitylation in immune defence and pathogen evasion. | |
| | |
MedLine Citation:
|
PMID: 22158412 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Ubiquitylation is a widely used post-translational protein modification that regulates many biological processes, including immune responses. The role of ubiquitin in immune regulation was originally uncovered through studies of antigen presentation and the nuclear factor-κB family of transcription factors, which orchestrate host defence against microorganisms. Recent studies have revealed crucial roles of ubiquitylation in many aspects of the immune system, including innate and adaptive immunity and antimicrobial autophagy. In addition, mounting evidence indicates that microbial pathogens exploit the ubiquitin pathway to evade the host immune system. Here, we review recent advances on the role of ubiquitylation in host defence and pathogen evasion. |
| | |
Authors:
|
Xiaomo Jiang; Zhijian J Chen |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-09 |
Journal Detail:
|
Title: Nature reviews. Immunology Volume: - ISSN: 1474-1741 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The impact of perinatal immune development on mucosal homeostasis and chronic inflammation.
Next Document: Molecular programming of B cell memory.