| The role of ubiquinones in the regulation of lipid metabolism in rat thymocytes. | |
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MedLine Citation:
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PMID: 2737295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of ubiquinones Q-1, Q-2, Q-8 and Q-9 on lipid metabolism in rat thymocytes in vitro was studied. The cells were incubated in a medium containing ubiquinones within the concentration range from 1 to 100 microM. A 2-fold decreased cholesterol synthesis was observed in thymocytes incubated with ubiquinone Q-9 at a concentration of exogenous ubiquinone of no less than 40 microM. Incubation of thymocytes with ubiquinones UQ-1 and UQ-2 that are characteristic of rats (40 microM and 100 microM) resulted in a decrease of cholesterol synthesis. Ubiquinone-8 had a tendency to inhibit the cholesterogenesis in rat thymocytes. |
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Authors:
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E G Novoselova |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: FEBS letters Volume: 249 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-07-28 Completed Date: 1989-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 371-4 Citation Subset: IM |
Affiliation:
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Institute of Biological Physics, USSR Academy of Sciences, Moscow Region. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / biosynthesis Lipid Metabolism* Male Rats Rats, Inbred Strains Thymus Gland / drug effects, metabolism* Ubiquinone / pharmacology* |
| Chemical | |
Reg. No./Substance:
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1339-63-5/Ubiquinone; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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