| The role of tumor necrosis factor-alpha in bone resorption of cholesteatoma. | |
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MedLine Citation:
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PMID: 1650149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent investigations have indicated that cytokines such as tumor necrosis factor-alpha (TNF-alpha) play a potential role in the bone resorption associated with inflammatory diseases. In this immunoperoxidase study, TNF-alpha was localized in mononuclear cells, macrophages, fibroblasts, osteoblasts, and osteoclasts adjacent to bone resorption areas in both human and experimental middle ear cholesteatomas. In vitro, TNF-alpha stimulated monocytes to form multinucleated cells that demonstrate tartrate-resistant acid phosphatase activity, a marker enzyme for osteoclasts. These multinucleated osteoclast-like cells induce resorption of devitalized bone. The extent of bone resorption was increased by the co-cultures of osteoblasts and osteoclasts in the presence of TNF-alpha, suggesting that cell to cell interaction plays a significant role in bone resorption. Moreover, TNF-alpha was capable of stimulating macrophages to produce acid phosphatase and collagenase, and osteoblasts to produce prostaglandin E2 and collagenase. These chemical mediators have been known to lead to bone resorption. Our findings suggest that TNF-alpha may play an important clinical role in the destructive process of cholesteatoma. |
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Authors:
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S D Yan; C C Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of otolaryngology Volume: 12 ISSN: 0196-0709 ISO Abbreviation: Am J Otolaryngol Publication Date: 1991 Mar-Apr |
Date Detail:
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Created Date: 1991-08-23 Completed Date: 1991-08-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8000029 Medline TA: Am J Otolaryngol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 83-9 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, College of Physicians and Surgeons, Columbia University, New York, NY 10032. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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analysis Animals Bone Marrow / drug effects, physiopathology Bone Resorption / pathology, physiopathology* Cells, Cultured Cholesteatoma / pathology, physiopathology* Dinoprostone / analysis Ear Diseases / pathology, physiopathology Ear, Middle Humans Immunoenzyme Techniques Macrophages / drug effects, physiology Microbial Collagenase / analysis Osteoblasts / drug effects, physiology Rats Tumor Necrosis Factor-alpha / pharmacology, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DC-00225/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tumor Necrosis Factor-alpha; 363-24-6/Dinoprostone; EC 3.1.3.2/Acid Phosphatase; EC 3.4.24.3/Microbial Collagenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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