Document Detail

The role of treatment modality on the utility of predictive tissue biomarkers in clinical prostate cancer: a systematic review.
MedLine Citation:
PMID:  23187933     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tissue biomarkers could pivotally improve clinical outcome prediction following prostate cancer therapy. Clinically, prostate cancer is managed by diverse treatment modalities whose individual influence on a biomarker's predictive ability is not well understood and poorly investigated in the literature.
OBJECTIVE: We conducted a systematic review to assess the predictive value of biomarkers in different treatment contexts in prostate cancer.
STUDY METHODOLOGY: A literature search was performed using the MeSH headings "prostate neoplasms" and "biological markers". Rigorous selection criteria identified studies correlating expression with clinical outcomes from primary androgen deprivation therapy (ADT), radical prostatectomy and radiotherapy (± neoadjuvant ADT).
STUDY RESULTS: Of 10,668 studies identified, 481 papers matched initial inclusion criteria. Following rescreening, 384 studies identified 236 individual tissue biomarkers, of which 29 were predictive on multivariate analysis in at least 2 independent cohorts. The majority were only tested in surgical cohorts. Only 8 predictive biomarkers were tested across all 3 treatments with Ki67 identified as universal predictive marker. p16 showed potential for treatment stratification between surgery and radiotherapy but needs further validation in independent studies.
CONCLUSIONS: Despite years of research, very few tissue biomarkers retain predictive value in independent validation across therapy context. Currently, none have conclusive ability to help treatment selection. Future biomarker research should consider the therapy context and use uniform methodology and evaluation criteria.
Naveen Kachroo; Vincent J Gnanapragasam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-28
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  139     ISSN:  1432-1335     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-02-18     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1-24     Citation Subset:  IM    
Translational Prostate Cancer Group, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.
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MeSH Terms
Androgen Antagonists / therapeutic use*
Angiogenic Proteins / metabolism
Antineoplastic Agents, Hormonal / therapeutic use*
Cell Adhesion Molecules / metabolism
Cell Cycle Proteins / metabolism
Cell Proliferation
Chemotherapy, Adjuvant
Intracellular Signaling Peptides and Proteins / metabolism
Ki-67 Antigen / metabolism*
Multivariate Analysis
Neoadjuvant Therapy / methods
Neoplasm Invasiveness
Neoplasm Proteins / metabolism
Neovascularization, Pathologic / metabolism
Predictive Value of Tests
Prostatic Neoplasms / blood supply,  drug therapy,  metabolism*,  radiotherapy,  surgery,  therapy*
Radiotherapy, Adjuvant
Research Report / standards*
Transcription Factors / metabolism
Tumor Markers, Biological / metabolism*
Reg. No./Substance:
0/Androgen Antagonists; 0/Angiogenic Proteins; 0/Antineoplastic Agents, Hormonal; 0/Cell Adhesion Molecules; 0/Cell Cycle Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Ki-67 Antigen; 0/Neoplasm Proteins; 0/P16 protein, human; 0/Transcription Factors; 0/Tumor Markers, Biological

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