| The role of transsphincteric pressure and proximal gastric volume in acid reflux before and after fundoplication. | |
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MedLine Citation:
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PMID: 16344058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: This study was conducted to explore the role of proximal gastric volume and transsphincteric pressure on acid reflux during transient lower esophageal sphincter relaxation (TLESR) in patients with gastroesophageal reflux disease (GERD) both before and after laparoscopic fundoplication. METHODS: Twenty GERD patients were studied before and after fundoplication along with 20 healthy controls. High-resolution manometry and pH recording was performed for 1 hour before and 2 hours following meal ingestion (500 mL/300 kcal). Three-dimensional ultrasonographic images of the stomach were acquired before and every 15 minutes after meal ingestion. RESULTS: Postprandial proximal to total gastric volume distribution ratios were significantly larger in GERD patients before fundoplication (0.57 +/- 0.01; P < .05) and smaller following fundoplication (0.37 +/- 0.01; P < .001) compared with controls (0.46 +/- 0.01). The percentage of TLESRs associated with acid reflux did not relate to proximal gastric volume in any subject group. The transsphincteric pressure profile was different for TLESRs with and without reflux in GERD patients as well as in healthy controls. The pressure gradient across the esophagogastric junction (EGJ) (DeltaEGJp) was greater for TLESRs with acid reflux compared with TLESRs without acid reflux in both GERD patients (11.4 +/- 0.8 vs 8.0 +/- 0.5 mm Hg, respectively; P < .01) and controls (10.6 +/- 0.7 vs 7.1 +/- 0.8 mm Hg, respectively; P < .05). After fundoplication, DeltaEGJp during TLESRs was 7.9 +/- 0.9 mm Hg, and the transsphincteric pressure profile markedly changed. CONCLUSIONS: Although proximal gastric volume plays a key role in eliciting TLESRs, it is not related to the incidence of acid reflux during TLESRs. The transsphincteric pressure gradient is greater in TLESRs associated with acid gastroesophageal reflux. |
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Authors:
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Robert C H Scheffer; Hein G Gooszen; Geoff S Hebbard; Melvin Samsom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology Volume: 129 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-13 Completed Date: 2006-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: United States |
Other Details:
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Languages: eng Pagination: 1900-9 Citation Subset: AIM; IM |
Affiliation:
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Gastrointestinal Research Unit, Department of Gastroenterology and Department of Surgery, University Medical Center, Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Diagnostic Techniques, Digestive System Esophageal Sphincter, Lower / metabolism* Female Fundoplication* Gastroesophageal Reflux / physiopathology* Humans Hydrogen-Ion Concentration Imaging, Three-Dimensional Laparoscopy Male Manometry Middle Aged Pressure Stomach* / anatomy & histology, physiology Ultrasonography / instrumentation, methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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