| The role of thrombophilia in splanchnic vein thrombosis. | |
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MedLine Citation:
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PMID: 18814082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the last few years, the mechanistic role of thrombophilia due to hypercoagulability and of clonal disorders of hemopoiesis such as chromosome Philadelphia-negative chronic myeloproliferative disorders has been increasingly recognized in primary splanchnic vein thrombosis. As in deep venous thrombosis of the lower limbs, the frequent finding of several prothrombotic disorders in the same individual has led to the concept of primary splanchnic vein thrombosis as a multifactorial disease. Significant progress has been made in determining the molecular bases of inherited thrombophilia, and particularly in the identification of molecular markers of clonal disease in the so-called occult or latent myeloproliferative disorders. In this review article, the authors discuss the current knowledge on the role of thrombophilia in extrahepatic portal vein obstruction and in the Budd-Chiari syndrome, two of the most clinically relevant splanchnic vein thromboses. |
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Authors:
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Massimo Primignani; Pier Mannuccio Mannucci |
Publication Detail:
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Type: Journal Article; Review Date: 2008-09-23 |
Journal Detail:
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Title: Seminars in liver disease Volume: 28 ISSN: 0272-8087 ISO Abbreviation: Semin. Liver Dis. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-09-24 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110297 Medline TA: Semin Liver Dis Country: United States |
Other Details:
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Languages: eng Pagination: 293-301 Citation Subset: IM |
Affiliation:
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Gastroenterology 3 Unit, Milan, Italy. primignani@policlinico.mi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Coagulation* Blood Coagulation Tests Budd-Chiari Syndrome / blood, etiology*, physiopathology Genetic Predisposition to Disease Humans Myeloproliferative Disorders / complications Risk Factors Splanchnic Circulation* Thrombophilia / blood, complications*, genetics, physiopathology Venous Thrombosis / blood, etiology*, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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