Document Detail

The role of thrombolytic therapy in the management of paradoxical embolism.
MedLine Citation:
PMID:  9705104     Owner:  NLM     Status:  MEDLINE    
Paradoxical emboli are considered a rare event, representing less than 2% of all arterial emboli. The most common intracardiac defect associated with paradoxical emboli is a patent foramen ovale. Most commonly, a pulmonary embolism is the cause of the acute increase in right atrial pressure leading to a reversal of intracardiac flow and passage of venous embolic material to the left heart. We present a patient with a pulmonary embolism and paradoxical emboli, and discuss therapeutic approach. We suggest that the treatment of choice for the patient with pulmonary embolism and non-limb-threatening acute ischemia due to a paradoxical emboli should be thrombolytic therapy and intracaval filter placement, followed by patent foramen ovale repair.
A d'Audiffret; S S Shenoy; J J Ricotta; M Dryjski
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  6     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-07     Completed Date:  1998-10-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  302-6     Citation Subset:  IM    
Department of Surgery, SUNY at Buffalo, New York, USA.
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MeSH Terms
Embolism, Paradoxical / drug therapy*
Heart Septal Defects, Atrial / surgery
Ischemia / etiology
Leg / blood supply
Plasminogen Activators / therapeutic use*
Pulmonary Embolism / drug therapy*
Thrombolytic Therapy*
Thrombosis / complications,  drug therapy
Urokinase-Type Plasminogen Activator / therapeutic use*
Vena Cava Filters
Reg. No./Substance:
EC 3.4.21.-/Plasminogen Activators; EC Plasminogen Activator

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