Document Detail


The role and therapeutic potential of monocytic cells in Alzheimer's disease.
MedLine Citation:
PMID:  20155817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alzheimer's disease (AD) is a dementing neurodegenerative disorder without a cure. The abnormal parenchymal accumulation of beta-amyloid (Abeta) is associated with inflammatory reactions involving microglia and astrocytes. Increased levels of Abeta and Abeta deposition in the brain are thought to cause neuronal dysfunction and underlie dementia. Microglia, the brain resident cells of monocytic origin, have a potential ability to phagocytose Abeta but they also react to Abeta by increased production of proinflammatory toxic agents. Microglia originate from hemangioblastic mesoderm during early embryonic stages and from bone marrow (BM)-derived monocytic cells that home the brain throughout the neonatal stage of development. Recent studies indicate that BM or blood-derived monocytes are recruited to the diseased AD brain, associate with the Abeta depositions, and are more efficient phagocytes of Abeta compared with resident microglia. The clearance of Abeta deposition by these cells has been recently under intensive investigation and can occur through several different mechanisms. Importantly, peripheral monocytic cells of patients with AD appear to be deficient in clearing Abeta. This review will summarize the findings on the role of blood-derived cells in AD and discuss their therapeutic potential for treating patients suffering from this devastating disease.
Authors:
Tarja Malm; Milla Koistinaho; Anu Muona; Johanna Magga; Jari Koistinaho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Glia     Volume:  58     ISSN:  1098-1136     ISO Abbreviation:  Glia     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806785     Medline TA:  Glia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  889-900     Citation Subset:  IM    
Affiliation:
Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / immunology,  pathology*,  therapy*
Amyloid beta-Protein / metabolism
Animals
Brain* / metabolism,  pathology,  physiopathology
Disease Models, Animal
Humans
Models, Biological
Monocytes / physiology*
Phagocytosis / immunology
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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