Document Detail

The role of therapeutic plasma exchange in the catastrophic antiphospholipid syndrome.
MedLine Citation:
PMID:  15951243     Owner:  NLM     Status:  MEDLINE    
The catastrophic antiphospholipid syndrome (CAPS) is a life-threatening sub-entity of the antiphospholipid syndrome (APS) resulting in multiorgan failure and a mortality rate that may reach 50%. The optimal treatment regimen for CAPS is unknown. To evaluate the benefit of therapeutic plasma exchange (TPE) therapy in CAPS, we undertook a computer-assisted (MEDLINE, National Library of Medicine, Bethesda, MD) search of the literature to locate all cases of CAPS (case reports and reviews) treated with TPE. In view of the published literature so far, TPE has shown reasonable therapeutic benefits and improved survival for patients with CAPS. The use of this technique, along with anticoagulation and if needed pharmacological immunosuppression, should be considered for the acute management of patients who present with this life-threatening condition.
Imad Uthman; Ali Shamseddine; Ali Taher
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis     Volume:  33     ISSN:  1473-0502     ISO Abbreviation:  Transfus. Apher. Sci.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-20     Completed Date:  2005-09-22     Revised Date:  2006-06-07    
Medline Journal Info:
Nlm Unique ID:  101095653     Medline TA:  Transfus Apher Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  11-7     Citation Subset:  T    
Department of Internal Medicine, Division of Rheumatology, American University of Beirut Medical Center (AUBMC), Hamra Street, Beirut 1107 2802, Lebanon.
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MeSH Terms
Antiphospholipid Syndrome / complications,  mortality,  therapy*
Catastrophic Illness / mortality
Plasma Exchange*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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