| The role of terlipressin in pediatric septic shock: a review of the literature and personal experience. | |
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MedLine Citation:
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PMID: 17624234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vasopressin and its synthetic analog terlipressin are potent vasopressors that could be useful in vasodilatory septic shock. In septic adults, vasopressin-terlipressin have been shown to increase mean arterial pressure and to decrease the necessity for catecholamines. Moreover, low doses of vasopressin, or terlipressin, increase urine output and ameliorate oxygenation. Although pediatric septic shock is more often hypodynamic, both vasopressin and terlipressin have proved to be effective in restoring blood pressure or increasing the diuresis in this setting. The purpose of this review is to summarize the physiology of vasopressin and to report the available evidence for the use of vasopressin or terlipressin in pediatric septic shock in order to make best use in this population. We also report our experience with the continuous infusion of terlipressin in two pediatric patients who developed catecholamine refractory septic shock. |
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Authors:
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P Papoff; M Mancuso; C S Barbara; C Moretti |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: International journal of immunopathology and pharmacology Volume: 20 ISSN: 0394-6320 ISO Abbreviation: Int J Immunopathol Pharmacol Publication Date: 2007 Apr-Jun |
Date Detail:
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Created Date: 2007-07-12 Completed Date: 2007-09-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8911335 Medline TA: Int J Immunopathol Pharmacol Country: Italy |
Other Details:
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Languages: eng Pagination: 213-21 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Pediatric Intensive Care Unit, University of Rome "La Sapienza", Italy. p.papoff@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Child Child, Preschool Humans Infant, Newborn Lypressin / analogs & derivatives*, physiology, therapeutic use Male Shock, Septic / drug therapy*, pathology Vasoconstrictor Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Vasoconstrictor Agents; 14636-12-5/terlipressin; 50-57-7/Lypressin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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