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The role of target therapies in schistosomiasis-associated pulmonary arterial hypertension.
MedLine Citation:
PMID:  22030800     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract BACKGROUND:Schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH) may be one of the most prevalent forms of pulmonary arterial hypertension (PAH) worldwide. However the clinical and hemodynamical response to specific PAH therapy in Sch-PAH is not known. METHODS:We retrospectively analyzed the charts of all Sch-PAH patients who initiated specific PAH treatment between June/2003 and June/2010 in a single PAH reference center in São Paulo, Brazil. Clinical and haemodynamical data were retrospectively collected and evaluated in two periods: baseline and post treatment. RESULTS:The study population consisted of 12 Sch-PAH patients. They were treated with phosphodiseterase-5 inhibitors (7 patients); endothelin receptors antagonists (4 patients) or combination therapy (1 patient). Mean treatment period was 34.9 ± 15.5 months. Patients with Sch-PAH presented significant improvements in terms of functional class, 6MWT distance (439±85 to 492±79m, p=0.032), cardiac index (2.66±0.59 to 3.08±0.68 L/min/m(2), p=0.028) and indexed pulmonary vascular resistance (20.7±11.6 to 15.9±9W/m(2), p=0.038) with the introduction of specific PAH-treatment. CONCLUSION:We conclude that specific PAH therapy may be of benefit to Sch-PAH patients, considering clinical, functional and hemodynamic parameters.
Authors:
Caio J C S Fernandes; Bruno A Dias; Carlos V P Jardim; Andre Hovnanian; Susana Hoette; Luciana K Morinaga; Silvia Souza; Milena Suesada; Ana P Breda; Rogério Souza
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-26
Journal Detail:
Title:  Chest     Volume:  -     ISSN:  1931-3543     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Cardio-Pulmonary Department - Heart Institute - University of Sao Paulo Medical School.
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