| The role of target therapies in schistosomiasis-associated pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 22030800 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract BACKGROUND:Schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH) may be one of the most prevalent forms of pulmonary arterial hypertension (PAH) worldwide. However the clinical and hemodynamical response to specific PAH therapy in Sch-PAH is not known. METHODS:We retrospectively analyzed the charts of all Sch-PAH patients who initiated specific PAH treatment between June/2003 and June/2010 in a single PAH reference center in São Paulo, Brazil. Clinical and haemodynamical data were retrospectively collected and evaluated in two periods: baseline and post treatment. RESULTS:The study population consisted of 12 Sch-PAH patients. They were treated with phosphodiseterase-5 inhibitors (7 patients); endothelin receptors antagonists (4 patients) or combination therapy (1 patient). Mean treatment period was 34.9 ± 15.5 months. Patients with Sch-PAH presented significant improvements in terms of functional class, 6MWT distance (439±85 to 492±79m, p=0.032), cardiac index (2.66±0.59 to 3.08±0.68 L/min/m(2), p=0.028) and indexed pulmonary vascular resistance (20.7±11.6 to 15.9±9W/m(2), p=0.038) with the introduction of specific PAH-treatment. CONCLUSION:We conclude that specific PAH therapy may be of benefit to Sch-PAH patients, considering clinical, functional and hemodynamic parameters. |
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Authors:
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Caio J C S Fernandes; Bruno A Dias; Carlos V P Jardim; Andre Hovnanian; Susana Hoette; Luciana K Morinaga; Silvia Souza; Milena Suesada; Ana P Breda; Rogério Souza |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-26 |
Journal Detail:
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Title: Chest Volume: - ISSN: 1931-3543 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Cardio-Pulmonary Department - Heart Institute - University of Sao Paulo Medical School. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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