Document Detail


The role of tamoxifen in combination with cisplatin on oral squamous cell carcinoma cell lines.
MedLine Citation:
PMID:  16513256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to evaluate the effect of tamoxifen (TAM) when used in combination with cisplatin on oral squamous cell carcinoma (OSCC). For this, the relation between estrogen receptor (ER) expression level and the cytotoxic effect of TAM, the apoptotic effect and its molecular mechanisms of TAM were investigated using OSCC cell lines. Combination treatment demonstrated a superior cytotoxic and apoptotic effect on OSCC cell lines. Considerable amount of ER was detected in some OSCC cell lines, but there were no significant differences of cytotoxic effect of TAM. TAM inhibited PKC activity and up-regulated TGF-beta1 secretion.
Authors:
Myung-Jin Kim; Jong-Ho Lee; Young-Kyun Kim; Hoon Myoung; Pil-Young Yun
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Publication Detail:
Type:  Journal Article     Date:  2006-03-02
Journal Detail:
Title:  Cancer letters     Volume:  245     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-04-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  284-92     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology
Apoptosis / drug effects*
Blotting, Western
Carcinoma, Squamous Cell / metabolism,  pathology
Cell Line, Tumor
Cell Survival / drug effects
Cisplatin / pharmacology*
Dose-Response Relationship, Drug
Drug Synergism
Flow Cytometry
Humans
Mouth Neoplasms / metabolism,  pathology
Protein Kinase C / metabolism
Receptors, Estrogen / metabolism
Tamoxifen / pharmacology*
Time Factors
Transforming Growth Factor beta1 / secretion
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Receptors, Estrogen; 0/Transforming Growth Factor beta1; 10540-29-1/Tamoxifen; 15663-27-1/Cisplatin; EC 2.7.11.13/Protein Kinase C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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