Document Detail


The role of systemic inflammatory biomarkers to predict mortality in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  23362815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors discuss the role of inflammatory biomarkers to predict mortality in chronic obstructive pulmonary disease (COPD) in this narrative literature review with expert opinion. The severity of COPD has traditionally been graded using the degree of obstruction as measured by the forced expiratory volume in 1 s because this variable has been predictive of outcomes. However, it is now accepted that COPD is a complex disease with important systemic consequences and that a multidimensional index such as the BMI, obstruction, dyspnea and exercise capacity index is a better predictor of outcome than lung function alone. Because inflammation is thought to play a pivotal role in the genesis of COPD, several serum inflammatory biomarkers have been investigated. Of the ones studied, C-reactive protein, IL-6, pulmonary and activation-regulated chemokine and fibronectin:C-reactive protein ratio have been observed to be independently associated with increased risk of death. When added to known clinical variables such as the BMI, obstruction, dyspnea and exercise capacity index, only IL-6 has been shown to further contribute to mortality prediction. It is likely that the use of an integrative approach combining biomarkers investigated through high-output technology with clinical parameters, combined with new information from the fields of genomics, transcriptomics, proteomics and metabolomics, will improve the authors capacity to predict mortality in COPD.
Authors:
Emer Kelly; Caroline A Owen; Victor Pinto-Plata; Bartolome R Celli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of respiratory medicine     Volume:  7     ISSN:  1747-6356     ISO Abbreviation:  Expert Rev Respir Med     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-07-19     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101278196     Medline TA:  Expert Rev Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
C-Reactive Protein*
Chemokines, CC / blood*
Fibronectins / blood*
Humans
Inflammation / blood,  mortality*
Interleukin-6 / blood*
Pulmonary Disease, Chronic Obstructive / blood,  mortality*
Uteroglobin / blood*
Grant Support
ID/Acronym/Agency:
F32 HL095276/HL/NHLBI NIH HHS; R01 HL063137/HL/NHLBI NIH HHS; R01 HL086814/HL/NHLBI NIH HHS; R21 HL111835/HL/NHLBI NIH HHS; T32 HL007633/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CCL18 protein, human; 0/Chemokines, CC; 0/Fibronectins; 0/Interleukin-6; 0/SCGB1A1 protein, human; 9007-41-4/C-Reactive Protein; 9060-09-7/Uteroglobin

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