Document Detail

The role of systematic data reviews in safety assessment of infant nutrition.
MedLine Citation:
PMID:  22699769     Owner:  NLM     Status:  In-Data-Review    
To make informed, evidence-based decisions regarding whether a given intervention is necessary, information about its benefits as well as harms is needed. Systematic reviews are always at the top of the evidence hierarchy. In general, the methodology for conducting systematic reviews of benefits and safety/harms overlaps. While systematic reviews of randomized controlled trials (RCTs) are sufficient for providing information regarding the efficacy and short-term safety aspects of these trials, they may be insufficient for providing adequate information about long-term safety and consequences. To adequately address harms, systematic reviews should include evidence from both RCTs and non-RCTs. The inclusion of the latter is to be considered particularly for addressing rare adverse effects, long-term adverse effects, or outcomes that were unknown at the time the RCTs were performed.
Hania Szajewska
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Publication Detail:
Type:  Journal Article     Date:  2012-06-06
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  60     ISSN:  1421-9697     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  204-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.
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