Document Detail

The role of sulfatide in thrombogenesis and haemostasis.
MedLine Citation:
PMID:  15158666     Owner:  NLM     Status:  MEDLINE    
In 1961, Wago et al. reported a potential anticoagulant role for sulfatide using animal experiments. Since then there have been many studies of sulfatide in the field of thrombogenesis/haemostasis, yielding contradictory conclusions. Some report that sulfatide has anti-thrombotic activity because it prolongs clotting time, inhibits platelet adhesion, and prolongs bleeding. Others report that sulfatide induces thrombosis in animal models. This mini-review is a chronologic review of reports examining the role of sulfatide in thrombogenesis/haemostasis together with the introduction of data from our laboratory and a discussion of the possible mechanisms underlying these curious phenomena.
Mamoru Kyogashima
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  426     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-25     Completed Date:  2004-07-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
Seikagaku Corporation, Central Research Laboratories, 1253 Tateno 3 chome, Higashiyamato-shi, Tokyo 207-0021, Japan.
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MeSH Terms
Anticoagulants / metabolism,  pharmacology
Blood Coagulation / drug effects*
Disease Models, Animal
Platelet Adhesiveness / drug effects*
Sulfoglycosphingolipids / metabolism*,  pharmacology*
Thrombosis / metabolism*
Venous Thrombosis / metabolism
Reg. No./Substance:
0/Anticoagulants; 0/Sulfoglycosphingolipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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