| The role of structure activity relationship studies in the search for new GABA uptake inhibitors. | |
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MedLine Citation:
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PMID: 18855736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system (CNS). A decrease in GABAergic neurotransmission seems to be involved in neurological pathologies such as epilepsy, anxiety and pain. This review is focus on structure activity relationship studies aiming the search for new GABA uptake inhibitors. |
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Authors:
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Katarzyna Kulig; Marta Szwaczkiewicz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Mini reviews in medicinal chemistry Volume: 8 ISSN: 1389-5575 ISO Abbreviation: Mini Rev Med Chem Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101094212 Medline TA: Mini Rev Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1214-23 Citation Subset: IM |
Affiliation:
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Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland. mfkkulig@cyf-kr.edu.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemistry, Pharmaceutical / methods Drug Design GABA Antagonists / metabolism GABA Plasma Membrane Transport Proteins / antagonists & inhibitors*, metabolism Humans Inhibitory Concentration 50 Mice Models, Biological Models, Chemical Neurotransmitter Agents / metabolism Rats Structure-Activity Relationship gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/GABA Antagonists; 0/GABA Plasma Membrane Transport Proteins; 0/Neurotransmitter Agents; 56-12-2/gamma-Aminobutyric Acid |
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