Document Detail

The role of structure activity relationship studies in the search for new GABA uptake inhibitors.
MedLine Citation:
PMID:  18855736     Owner:  NLM     Status:  MEDLINE    
gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system (CNS). A decrease in GABAergic neurotransmission seems to be involved in neurological pathologies such as epilepsy, anxiety and pain. This review is focus on structure activity relationship studies aiming the search for new GABA uptake inhibitors.
Katarzyna Kulig; Marta Szwaczkiewicz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  8     ISSN:  1389-5575     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-15     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1214-23     Citation Subset:  IM    
Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
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MeSH Terms
Chemistry, Pharmaceutical / methods
Drug Design
GABA Antagonists / metabolism
GABA Plasma Membrane Transport Proteins / antagonists & inhibitors*,  metabolism
Inhibitory Concentration 50
Models, Biological
Models, Chemical
Neurotransmitter Agents / metabolism
Structure-Activity Relationship
gamma-Aminobutyric Acid / metabolism*
Reg. No./Substance:
0/GABA Antagonists; 0/GABA Plasma Membrane Transport Proteins; 0/Neurotransmitter Agents; 56-12-2/gamma-Aminobutyric Acid

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