Document Detail

The role of stromal cells in the persistence of chronic inflammation.
MedLine Citation:
PMID:  23199320     Owner:  NLM     Status:  MEDLINE    
Inflammation is an unstable state; it either resolves or persists. Inflammatory reactions often have a propensity for specific anatomical sites. Why inflammation persists with specific tissue tropism remains obscure. Increasing evidence suggests that stromal cells which define tissue architecture are the key cells involved, and therefore make attractive therapeutic targets. Research on stromal cells in general and fibroblasts in particular has so far been hampered by a lack of fibroblast-specific cell markers. This review highlights our increasing understanding of the role of fibroblasts in inflammation, and suggests that these cells provide the cellular basis for site specific chronic inflammation.
A J Naylor; A Filer; C D Buckley
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-19     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology.
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MeSH Terms
Chronic Disease
Fibroblasts / immunology
Inflammation / immunology*
Leukocytes / immunology
Stromal Cells / immunology*
Grant Support
20088//Arthritis Research UK

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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