Document Detail


The role of stressor intensity and underlying vasculopathy in altering coronary reactivity in cardiomyopathic hamsters.
MedLine Citation:
PMID:  9021866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Our previous work showed that stress sensitized the vessels of cardiomyopathic hamsters (CMHs), but only hamsters in the lesion-forming period of their life. We hypothesized that we would find an interaction between stressor intensity and microvascular vulnerability. METHOD: Male CMHs at ages of 1.5, 2.5, and 3.5 months were stressed with supine immobilization for five consecutive days. Stressor intensity was manipulated by immobilizing groups of CMHs at room temperature for 0 minutes, 15 minutes, 30 minutes, 1 hour, or 2 hours. CMHs were anesthetized and sacrificed 5 days after stress, and their hearts were perfused using a modified Langendorff system. Body weight changes and baseline coronary vascular resistance (CVR) were recorded, and CVR was also measured after coronary artery infusion of arginine vasopressin (AVP). RESULTS: Stress produced no effect on coronary vasculature in 1.5-month-old CMHs. In 2.5-month-old CMHs, only the two highest-intensity stressors enhanced coronary reactivity to AVP. In 3.5-month-old CMHs, higher-intensity stressors produced a marginal AVP-induced increase in CVR; but this marginal increase was significantly lower than the increases seen with the two highest-stressor intensities in the 2.5-month-old CMHs. CONCLUSION: The stress-induced coronary hyperreactivity to AVP seen in 2.5-month-old CMHs diminished when microvascular vulnerability was lower in 3.5-month-old CMHs. For 1.5-month-old CMHs, the resting CVR was extremely high, so that the addition of stress produced no further increase. Thus, stressor intensity interacted with microvascular vulnerability to alter the consequences of stress.
Authors:
Q Chang; B H Natelson; C D Goldstein; J E Ottenweller
Related Documents :
108966 - Arteriographic demonstration of spontaneous right coronary artery spasm in a patient wi...
828456 - Prinzmetal's angina with coronary artery spasm. angiographic, pharmacologic, metabolic ...
6794936 - Coronary arterial spasm in single coronary artery.
20039506 - Coronary artery spasm as a cause of chest pain and re-elevation of st segment and cardi...
23143206 - Large aneurysm of left coronary sinus of valsalva presenting with effort-related ventri...
16498506 - Genetic determinants of vascular remodelling.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Psychosomatic medicine     Volume:  59     ISSN:  0033-3174     ISO Abbreviation:  Psychosom Med     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-04-28     Completed Date:  1997-04-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM; S    
Affiliation:
Neurobehavioral Unit, Veterans Administration Medical Center, East Orange, NJ 07018-1095, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age Factors
Analysis of Variance
Animals
Arginine Vasopressin / adverse effects
Cardiomyopathies / complications,  physiopathology*
Cricetinae
Disease Models, Animal*
Disease Progression
Disease Susceptibility
Male
Restraint, Physical / adverse effects
Stress, Physiological / complications,  physiopathology*
Vascular Resistance / drug effects,  physiology
Chemical
Reg. No./Substance:
113-79-1/Arginine Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Circadian immune measures in healthy volunteers: relationship to hypothalamic-pituitary-adrenal axis...
Next Document:  Cognitive slowing and working memory difficulties in chronic fatigue syndrome.