Document Detail

The role of stressor intensity and underlying vasculopathy in altering coronary reactivity in cardiomyopathic hamsters.
MedLine Citation:
PMID:  9021866     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our previous work showed that stress sensitized the vessels of cardiomyopathic hamsters (CMHs), but only hamsters in the lesion-forming period of their life. We hypothesized that we would find an interaction between stressor intensity and microvascular vulnerability. METHOD: Male CMHs at ages of 1.5, 2.5, and 3.5 months were stressed with supine immobilization for five consecutive days. Stressor intensity was manipulated by immobilizing groups of CMHs at room temperature for 0 minutes, 15 minutes, 30 minutes, 1 hour, or 2 hours. CMHs were anesthetized and sacrificed 5 days after stress, and their hearts were perfused using a modified Langendorff system. Body weight changes and baseline coronary vascular resistance (CVR) were recorded, and CVR was also measured after coronary artery infusion of arginine vasopressin (AVP). RESULTS: Stress produced no effect on coronary vasculature in 1.5-month-old CMHs. In 2.5-month-old CMHs, only the two highest-intensity stressors enhanced coronary reactivity to AVP. In 3.5-month-old CMHs, higher-intensity stressors produced a marginal AVP-induced increase in CVR; but this marginal increase was significantly lower than the increases seen with the two highest-stressor intensities in the 2.5-month-old CMHs. CONCLUSION: The stress-induced coronary hyperreactivity to AVP seen in 2.5-month-old CMHs diminished when microvascular vulnerability was lower in 3.5-month-old CMHs. For 1.5-month-old CMHs, the resting CVR was extremely high, so that the addition of stress produced no further increase. Thus, stressor intensity interacted with microvascular vulnerability to alter the consequences of stress.
Q Chang; B H Natelson; C D Goldstein; J E Ottenweller
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Psychosomatic medicine     Volume:  59     ISSN:  0033-3174     ISO Abbreviation:  Psychosom Med     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-04-28     Completed Date:  1997-04-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM; S    
Neurobehavioral Unit, Veterans Administration Medical Center, East Orange, NJ 07018-1095, USA.
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MeSH Terms
Age Factors
Analysis of Variance
Arginine Vasopressin / adverse effects
Cardiomyopathies / complications,  physiopathology*
Disease Models, Animal*
Disease Progression
Disease Susceptibility
Restraint, Physical / adverse effects
Stress, Physiological / complications,  physiopathology*
Vascular Resistance / drug effects,  physiology
Reg. No./Substance:
113-79-1/Arginine Vasopressin

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