| The role of stress in female reproduction and pregnancy: an update. | |
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MedLine Citation:
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PMID: 20840255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Life exists by establishing a balanced equilibrium, called homeostasis, constantly challenged by adverse stimuli, called stressors. In response to these stimuli, a complex neurohormonal reaction exerted by the activation of the so-called stress system is initiated. The latter is activated in a coordinated fashion, leading to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chance for survival. The stress system suppressive effects on female reproduction involve suppression of the hypothalamic-pituitary-ovarian axis at the hypothalamic, pituitary, ovarian, and uterine levels. Experimental and human data suggest that adverse prenatal stimuli, of either maternal or fetal origin, acting in the developing embryo in utero, can lead to the development of short- and long-term health disorders. These include preterm birth of the offspring, low birth weight, and the development of adult diseases ranging from the metabolic syndrome to several neurodevelopmental disorders. |
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Authors:
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Thomas Vrekoussis; Sophia N Kalantaridou; George Mastorakos; Emmanuel Zoumakis; Antonis Makrigiannakis; Marika Syrrou; Lazaros G Lavasidis; Kostas Relakis; George P Chrousos |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1205 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2010-09-28 Revised Date: 2010-10-19 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 69-75 Citation Subset: IM |
Copyright Information:
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© 2010 New York Academy of Sciences. |
Affiliation:
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Department of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina, Greece. tvrek@med.uoc.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Corticotropin-Releasing Hormone / metabolism, physiology Female Humans Models, Biological Pregnancy Pregnancy Complications / physiopathology*, psychology Pregnancy Outcome Reproduction / physiology* Stress, Psychological / complications, physiopathology* |
| Chemical | |
Reg. No./Substance:
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9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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