Document Detail

The role of speed versus working memory in predicting learning new information in multiple sclerosis.
MedLine Citation:
PMID:  23350959     Owner:  NLM     Status:  Publisher    
The most common cognitive impairments in multiple sclerosis (MS) have been documented in specific domains, including new learning and memory, working memory, and information processing speed. However, little attempt has been made to increase our understanding of their relationship to one another. While recent studies have shown that processing speed impacts new learning and memory abilities in MS, the role of working memory in this relationship has received less attention. The present study examines the relative contribution of impaired working memory versus processing speed in new learning and memory functions in MS. Participants consisted of 51 individuals with clinically definite MS. Participants completed two measures of processing speed, two measures of working memory, and two measures of episodic memory. Data were analyzed via correlational and multiple regression analysis. Results indicate that the variance in new learning abilities in this sample was primarily associated with processing speed, with working memory exerting much less of an influence. Results are discussed in terms of the role of cognitive rehabilitation of new learning and memory abilities in persons with MS. This project was supported by Grants RG 3330A and MB003 from the National Multiple Sclerosis Society and the Kessler Foundation.
Nancy D Chiaravalloti; Jelena Stojanovic-Radic; John Deluca
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Journal of clinical and experimental neuropsychology     Volume:  -     ISSN:  1744-411X     ISO Abbreviation:  J Clin Exp Neuropsychol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502170     Medline TA:  J Clin Exp Neuropsychol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Kessler Foundation Research Center, Neuropsychology and Neuroscience Laboratory , West Orange , NJ , USA.
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