| The role of some central catecholamine systems in cholecystokinin-induced satiety. | |
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MedLine Citation:
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PMID: 6324148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholecystokinin (CCK), bombesin and gastrin were stereotaxically injected into catecholamine (CA) innervated areas of the lateral hypothalamus (LH), the nucleus caudatus putamen (NP) and the olfactory tubercle (OT) in male Sprague Dawley rats. Bilateral injections of 100 ng of CCK in 2 microliters of vehicle into the LH produced a slight but significant decrease in food intake during the first hour of a 4 hour eating test. The other peptides when injected into any of the brain areas did not significantly alter food intake. Water intake was affected by the injection of all three hormones although differentially in all 3 sites. The observed changes in drinking were not related to the prandial characteristics of drinking typically seen in rodents. Denervation of the CA innervation of the OT, LH or NP with 6-hydroxydopamine did not change the satiety response to peripherally administered CCK displayed by intact animals. These results suggest that the satiety which occurs after the central and peripheral administration of CCK may be mediated by different mechanisms and that central CA systems may not be necessary for CCK-induced satiety to occur during natural feeding. |
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Authors:
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G L Willis; J Hansky; G C Smith |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Peptides Volume: 5 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1984 Jan-Feb |
Date Detail:
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Created Date: 1984-05-21 Completed Date: 1984-05-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 41-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bombesin / pharmacology Catecholamines / physiology* Gastrins / pharmacology Hypothalamus / drug effects, physiology* Kinetics Male Olfactory Bulb / drug effects, physiology* Putamen / drug effects, physiology* Rats Rats, Inbred Strains Satiation / drug effects* Sincalide / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Gastrins; 25126-32-3/Sincalide; 31362-50-2/Bombesin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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