Document Detail

The role of some central catecholamine systems in cholecystokinin-induced satiety.
MedLine Citation:
PMID:  6324148     Owner:  NLM     Status:  MEDLINE    
Cholecystokinin (CCK), bombesin and gastrin were stereotaxically injected into catecholamine (CA) innervated areas of the lateral hypothalamus (LH), the nucleus caudatus putamen (NP) and the olfactory tubercle (OT) in male Sprague Dawley rats. Bilateral injections of 100 ng of CCK in 2 microliters of vehicle into the LH produced a slight but significant decrease in food intake during the first hour of a 4 hour eating test. The other peptides when injected into any of the brain areas did not significantly alter food intake. Water intake was affected by the injection of all three hormones although differentially in all 3 sites. The observed changes in drinking were not related to the prandial characteristics of drinking typically seen in rodents. Denervation of the CA innervation of the OT, LH or NP with 6-hydroxydopamine did not change the satiety response to peripherally administered CCK displayed by intact animals. These results suggest that the satiety which occurs after the central and peripheral administration of CCK may be mediated by different mechanisms and that central CA systems may not be necessary for CCK-induced satiety to occur during natural feeding.
G L Willis; J Hansky; G C Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  5     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-05-21     Completed Date:  1984-05-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
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MeSH Terms
Bombesin / pharmacology
Catecholamines / physiology*
Gastrins / pharmacology
Hypothalamus / drug effects,  physiology*
Olfactory Bulb / drug effects,  physiology*
Putamen / drug effects,  physiology*
Rats, Inbred Strains
Satiation / drug effects*
Sincalide / pharmacology*
Reg. No./Substance:
0/Catecholamines; 0/Gastrins; 25126-32-3/Sincalide; 31362-50-2/Bombesin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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