| The role of small airways in lung disease. | |
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MedLine Citation:
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PMID: 11862964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The small airways constitute one of the least understood areas of the lungs. They play a role in many lung diseases, and small airway pathology results in significant morbidity New approaches to their evaluation may provide insights into this major area of lung disease. Asthma is well recognized as a disease of both large and small airways. Physiological and pathological evidence, from techniques such as post-mortem tissue histological analysis, induced sputum and transbronchial biopsies, has reinforced the concept of the involvement of the entire bronchial tree n the inflammatory process in asthma, In addition to describing the airway pathology in asthma, th s review focuses on the pathogenesis and role of small airway obstruction n other diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), sarcoidosis and obliterative bronchiolitis (OB). COPD is characterized by the presence of airflow obstruction resulting from lesions in the small airways. In addition, features compatible with small airways disease are common in IPF, sarcoidosis and OB. Recent advances in pulmonary imaging, such as high-resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) with hyperpolarized 3He, have allowed non-invasive reproducible measurements of structure-function relationships to be made for the small airways. These techniques have great potential for diagnosing changes in small airway function and for assessing responses to treatment. New insights into the contribution of small airways to a range of lung diseases may lead to the development of therapies targeted at this part of the bronchial anatomy. |
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Authors:
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R J Shaw; R Djukanovic; D P Tashkin; A B Millar; R M du Bois; P A Orr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Respiratory medicine Volume: 96 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-25 Completed Date: 2002-03-13 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 67-80 Citation Subset: IM |
Affiliation:
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NHLI, Imperial College, Hammersmith Hospital, London, UK. r.shaw@ic.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchi
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pathology* Bronchiolitis Obliterans / drug therapy, pathology Drug Delivery Systems Glucocorticoids / therapeutic use Humans Lung Diseases / drug therapy, pathology* Magnetic Resonance Imaging Pulmonary Disease, Chronic Obstructive / drug therapy, pathology Pulmonary Fibrosis / drug therapy, pathology Respiratory Function Tests Sarcoidosis / drug therapy, pathology Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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