| The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation. | |
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MedLine Citation:
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PMID: 22427524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The signaling complex consisting of the growth factor neuregulin-1 (NRG1) and its tyrosine kinase receptors ErbB2 and ErbB4 has a critical role in cardiac development and homeostasis of the structure and function of the adult heart. Recent research results suggest that targeting this signaling complex may provide a viable strategy for treating heart failure. Clinical trials are currently evaluating the effectiveness and safety of intravenous administration of recombinant NRG1 formulations in heart failure patients. Endogenous as well as administered NRG1 has multiple possible activities in the adult heart, but how these are related is unknown. It has recently been demonstrated that NRG1 administration can stimulate proliferation of cardiomyocytes, which may contribute to repair failing hearts. This review summarizes the current knowledge of how NRG1 and its receptors control cardiac physiology and biology, with special emphasis on its role in cardiomyocyte proliferation during myocardial growth and regeneration. |
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Authors:
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Brian Wadugu; Bernhard Kühn |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-03-16 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 302 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-04 Completed Date: 2012-09-12 Revised Date: 2013-05-15 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H2139-47 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Children's Hospital Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation* Heart Failure / drug therapy Humans Mice Models, Animal Myocytes, Cardiac / cytology, physiology* Neuregulin-1 / therapeutic use Neuregulins / physiology*, therapeutic use Rats Receptor, Epidermal Growth Factor / physiology* Receptor, erbB-2 / physiology* Recombinant Proteins / therapeutic use Signal Transduction / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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K08 HL085143/HL/NHLBI NIH HHS; K08-HL-085143/HL/NHLBI NIH HHS; R01 HL106302/HL/NHLBI NIH HHS; R01-HL-106302/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuregulin-1; 0/Neuregulins; 0/Recombinant Proteins; EC 2.7.10.1/Receptor, Epidermal Growth Factor; EC 2.7.10.1/Receptor, erbB-2; EC 2.7.10.1/receptor tyrosine-protein kinase erbB-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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