Document Detail

The role of sialoglycoconjugates in the aging and sequestration of red cells from circulation.
MedLine Citation:
PMID:  3179457     Owner:  NLM     Status:  MEDLINE    
Red blood cells (rbcs) have a definite life-span in circulation, 120 days in humans (and 60 days in rat). This involves the turnover of the equivalent of 2 x 10(11) rbcs per day in a normal adult. Many time-dependent physical, chemical, as well as biochemical and immunologic changes are associated with in vivo aging of rbcs in circulation. The major difficulty has been to unravel the complex picture and assign the primary signal responsible for the sequestration of the senescent rbc from circulation. Our current hypothesis based on the results of studies from many laboratories including our own is that it involves the progressive desialation of the most abundant sialoglycoprotein on rbc surface, glycophorin A. The complete desialation of glycophorin results in the exposure of multiple galactose-beta(1,3) N-acetylgalactosamine disaccharide residues on the rbc surface. These sites are recognized by the reticuloendothelial system, and result in the sequestration of those desialated senescent rbcs from circulation. This review summarizes the evidence for and against the immediate acceptance of this hypothesis.
D Aminoff
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood cells     Volume:  14     ISSN:  0340-4684     ISO Abbreviation:  Blood Cells     Publication Date:  1988  
Date Detail:
Created Date:  1988-11-29     Completed Date:  1988-11-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513567     Medline TA:  Blood Cells     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  229-57     Citation Subset:  IM    
Department of Biological Chemistry, University of Michigan, Ann Arbor 48109-2007.
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MeSH Terms
Biological Assay
Erythrocyte Aging*
Glycoside Hydrolases / physiology
Models, Biological
Sialoglycoproteins* / physiology*
Grant Support
Reg. No./Substance:
0/Glycophorin; 0/Sialoglycoproteins; EC 3.2.1.-/Glycoside Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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