Document Detail

The role of shear stress in the pathogenesis of discrete subaortic stenosis: implications for surgical treatment.
MedLine Citation:
PMID:  21560809     Owner:  NLM     Status:  In-Process    
Discrete subaortic stenosis (DSS) is characterized by the presence of an obstructing membrane in the left ventricular outflow tract (LVOT). Evidence suggests that the formation of DSS represents a fibroproliferative reaction of the endocardium occurring in response to alterations in shear stress caused by geometric abnormalities within the LVOT. The aim of this review is to discuss the role of altered LVOT shear stress in the pathogenesis of DSS, and its implications in surgical decision making.
Jeffrey J Silbiger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  20     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-05-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Mount Sinai School of Medicine, New York City, NY, USA.
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