Document Detail

The role of serum and urinary urea in the evaluation of enteral protein intake in adequate and small-for-gestational-age very low birth weight infants.
MedLine Citation:
PMID:  16444384     Owner:  NLM     Status:  MEDLINE    
CONTEXT AND OBJECTIVE: Very low birth weight (VLBW) infants have special nutritional needs. There is a current tendency to individualize their protein needs. The objective of this study was to determine the suitability of serum and urinary urea as indicators for protein intake in adequate-for-gestational-age (AGA) and small-for-gestational-age (SGA) VLBW infants.
DESIGN AND SETTING: Prospective study in the nursery attached to the Maternity Ward of the "Prof. Pedro de Alcântara" Children's Institute, Hospital das Clínicas, Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, Brazil.
METHODS: Seventy-two VLBW infants (mean protein intake = 3.7 mg/kg/day) were enrolled in a prospective cohort study in two groups: AGA (n = 34) and SGA (n = 38). Blood samples, six-hour urine (6hUr) collections and urine sample tests (STUr) were obtained for urea and creatinine assays at three and five weeks of life.
STATISTICAL ANALYSIS: Student's t test, Pearson correlation and linear regression (p < 0.05).
RESULTS: There were no differences between groups for serum urea, 6hUr and STUr, or between two assessments within each group. Serum urea correlated with 6hUr in both AGA and SGA, and to STUr in SGA; 6hUr correlated with STUr in both AGA and SGA. There was no correlation between protein intake and serum or urine urea.
CONCLUSIONS: Serum and urinary urea did not reflect protein intake when mean intakes of 3.7 g/kg/day were used. Sample tests of urinary urea can be as reliable as urea from urine collected over longer periods.
Silvana Darcie; Cléa Rodrigues Leone
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Publication Detail:
Type:  Journal Article     Date:  2006-01-20
Journal Detail:
Title:  São Paulo medical journal = Revista paulista de medicina     Volume:  123     ISSN:  1516-3180     ISO Abbreviation:  Sao Paulo Med J     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2007-08-13     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  100897261     Medline TA:  Sao Paulo Med J     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood,  urine
Creatinine / blood,  urine
Dietary Proteins / administration & dosage,  metabolism*
Energy Intake / physiology*
Epidemiologic Methods
Gestational Age
Infant, Newborn
Infant, Small for Gestational Age / blood,  metabolism*,  urine
Infant, Very Low Birth Weight / blood,  metabolism*,  urine
Urea / analysis*,  blood,  urine
Reg. No./Substance:
0/Biological Markers; 0/Dietary Proteins; 8W8T17847W/Urea; AYI8EX34EU/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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