| The role of serum adipocyte fatty acid-binding protein on the development of metabolic syndrome is independent of pro-inflammatory cytokines. | |
| | |
MedLine Citation:
|
PMID: 21186114 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND AND AIM: Adipocyte fatty acid-binding protein (FABP4) is abundantly expressed in adipocytes and plays a role in glucose homeostasis. We analysed the relationship between serum FABP4 levels and the progression of metabolic syndrome in healthy adults. METHODSAND RESULTS: A total of 465 subjects were selected from participants in a medical check-up programme at a Health Promotion Center. Baseline serum FABP4 levels were measured, and the subjects were evaluated for the presence of metabolic syndrome (MetS) according to the recommendations of the American Heart Association/National Heart, Lung, and Blood Institute. The subjects were re-evaluated 4 years later. Baseline FABP4 concentrations were significantly higher in subjects with MetS than in those without MetS (P<0.001). At the 4-year follow-up, subjects in the highest FABP4 tertile at baseline exhibited higher values for body mass index, fat mass and percent body fat, as well as blood pressure, fasting glucose, total cholesterol, triglycerides, low-density lipoprotein (LDL)-cholesterol, insulin, homeostasis model assessment of insulin resistance, monocyte chemoattractant protein-1 and tumor necrosis factor-α levels (all P<0.05). The subjects with higher FABP4 levels had lower HDL-cholesterol concentrations (P<0.05). After adjustment for age, sex, change in percent body fat and baseline values for other metabolic and inflammatory parameters, FABP4 levels at baseline were shown to be strongly associated with the development of MetS by year 4 (odds ratio (OR), 5.75; 95% confidence interval (CI), 2.71-12.23 for highest tertile vs. lowest tertile, P<0.001) CONCLUSION: Baseline serum FABP4 levels appear to be a significant predictor for the future development of MetS, independent of pro-inflammatory cytokines. |
| | |
Authors:
|
S E Park; E-J Rhee; W-Y Lee; W-J Kim; S-H Yoo; J-C Bae; E-S Choi; C-Y Park; K-W Oh; S-W Park; S-W Kim |
Related Documents
:
|
2769074 - Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plas... 21443484 - Mediterranean diet rich in olive oil and obesity, metabolic syndrome and diabetes melli... 3895954 - Theoretical effects of amniotic fluid volume changes on surfactant concentration measur... 7126624 - Effect of dietary fat saturation, cholesterol and cholestyramine on acyl-coa: cholester... 12665164 - Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxi... 8749274 - Diagnostic value of immune cholesterol as a marker for atherosclerosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-24 |
Journal Detail:
|
Title: Nutrition, metabolism, and cardiovascular diseases : NMCD Volume: - ISSN: 1590-3729 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9111474 Medline TA: Nutr Metab Cardiovasc Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, No. 108 Pyung-Dong, Jongro-Ku, Seoul 110-746, Republic of Korea; Department of Medicine, Graduate School, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A derangement of the maternal lipid profile is associated with an elevated risk of congenital heart ...
Next Document: A performance-based system for the long-term management of municipal waste landfills.