| The role of serotonin in hot flushes. | |
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MedLine Citation:
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PMID: 11063896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hot flushes are experienced in those periods of the female life when estrogen levels are low. Hormone replacement therapy is thus the first choice for treatment of hot flushes. However this treatment is not always accepted or contraindicated for a variety of reasons. Estrogen (and progestogen) strongly interact with a number of neurotransmitters and this has led to a range of non-hormonal treatments including compounds that act via the noradrenergic or dopaminergic systems as well as herbal remedies. These treatments (which are shortly reviewed) are not always successful. Surprisingly, apart from treatment with some selective serotonin (5-HT) reuptake inhibitors (SSRI's), up till now, little attention is given to the strong interaction of estrogens with the serotonergic system. These interactions are shortly reviewed. Based on these interactions, a hypothesis on the genesis of hot flushes is postulated. Especially the 5-HT(2A) receptor subtype may play a key role in the occurrence of hot flushes. A number of arguments that support this hypothesis are discussed. |
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Authors:
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H H Berendsen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Maturitas Volume: 36 ISSN: 0378-5122 ISO Abbreviation: Maturitas Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-01-16 Completed Date: 2001-01-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7807333 Medline TA: Maturitas Country: IRELAND |
Other Details:
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Languages: eng Pagination: 155-64 Citation Subset: IM |
Affiliation:
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Pharmacology Department, N.V. Organon, POB 20, 5340 BH, Oss, Netherlands. h.berendsen@organon.oss.akzonobel.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Estrogens
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physiology* Female Hormone Replacement Therapy Hot Flashes / drug therapy, etiology*, physiopathology Humans Menopause / physiology Progesterone / physiology Receptors, Serotonin / physiology* Serotonin / physiology* Serotonin Uptake Inhibitors / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Receptors, Serotonin; 0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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