Document Detail

The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory.
MedLine Citation:
PMID:  10493166     Owner:  NLM     Status:  MEDLINE    
The role of self-antigen recognition in the development of T and B cells of the adaptive immune system has been studied in several different ways. We have shown that CD4 T cells are selected on self-peptide:self-MHC class II ligands, and in the periphery, they are sustained by contact with the same or similar ligands. We have also observed that B cells are positively selected on unknown and presumed self-ligands. We have used this information to explore autoimmune diseases as well. Finally, we have recently identified the innate immune system as playing a crucial role in regulating expression of costimulatory molecules that are required for induction of adaptive immune responses.
C A Janeway
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunologic research     Volume:  19     ISSN:  0257-277X     ISO Abbreviation:  Immunol. Res.     Publication Date:  1999  
Date Detail:
Created Date:  1999-12-14     Completed Date:  1999-12-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8611087     Medline TA:  Immunol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-18     Citation Subset:  IM    
Section of Immunobiology, Yale University School of Medicine, and The Howard Hughes Medical Institute, New Haven, CT 06520-8011, USA.
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MeSH Terms
Autoantigens / immunology*
Autoimmune Diseases / immunology
Disease Models, Animal
Immunity, Innate
Major Histocompatibility Complex
Receptors, Antigen, B-Cell / immunology*
Receptors, Antigen, T-Cell / immunology*
Reg. No./Substance:
0/Autoantigens; 0/Receptors, Antigen, B-Cell; 0/Receptors, Antigen, T-Cell

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