| The role of selenium in the secretion of very-low-density lipoprotein in the isolated perfused rat liver. | |
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MedLine Citation:
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PMID: 1953666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A recirculating liver perfusion system was used to study the effects of dietary selenium (Se) on the hepatic secretion of very-low-density lipoprotein (VLDL). The perfusate from livers of rats fed on a Se-deficient diet incorporated about 50% more [1-14C]oleic acid into triacylglycerol (TG) and cholesteryl esters (ChoEs) than did the perfusate from livers of rats fed on a Se-supplemented diet. Similarly, livers from rats fed the Se-deficient diet secreted more VLDL and incorporated about 60% more [1-14C]oleic acid into VLDL TG and ChoEs than did livers from rats fed the Se-supplemented diet. The liver perfusate from rats in the Se-deficient group also showed significantly decreased fatty acid oxidation. We conclude that Se is a potent modulator of lipoprotein metabolism. A primary action of Se deficiency appears to be a decrease in fatty acid oxidation and a stimulation of fatty acid esterification, leading to increased VLDL TG and ChoEs formation and secretion. |
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Authors:
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R L Scott; A Kheshti; M Heimberg; H G Wilcox; W L Stone |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Biochemical journal Volume: 279 ( Pt 3) ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1991-12-16 Completed Date: 1991-12-16 Revised Date: 2010-09-09 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 741-5 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Glutathione Peroxidase / metabolism Lipoproteins, VLDL / secretion* Liver / chemistry, enzymology, secretion* Male Oleic Acid Oleic Acids / metabolism Organ Size Oxidation-Reduction Perfusion Rats Rats, Inbred SHR Selenium / deficiency, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-01779/HL/NHLBI NIH HHS; HL-27850/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, VLDL; 0/Oleic Acids; 112-80-1/Oleic Acid; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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