Document Detail

The role of secretin in the inhibition of gastric secretion by intraduodenal acid.
MedLine Citation:
PMID:  4455567     Owner:  NLM     Status:  MEDLINE    
The effect of intraduodenal acid on pentagastrin-stimulated gastric secretion has been investigated in 12 normal subjects and 23 patients with chronic duodenal ulceration. Plasma secretin levels were monitored during each test using a highly sensitive radioimmunoassay. Significant inhibition of gastric secretion occurred in the normal subjects and duodenal ulcer patients. A significant rise in plasma secretin was observed in both groups after intraduodenal acid though there was a complete lack of correlation between the magnitude of the secretin response and the degree of gastric inhibition. Ten subjects received intraduodenal acid and a subsequent intravenous infusion of exogenous secretin (0.125-0.25 units/kg over six minutes). Gastric inhibition occurred after the acid instillation but not after secretin infusion despite plasma secretin levels greatly in excess of those produced by intraduodenal acid. These results suggest that release of secretin by itself cannot explain the gastric inhibitory response to intraduodenal acid in man.
A S Ward; S R Bloom
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  15     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1974 Nov 
Date Detail:
Created Date:  1975-06-21     Completed Date:  1975-06-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  889-97     Citation Subset:  AIM; IM    
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MeSH Terms
Gastric Juice / secretion*
Gastric Mucosa / drug effects*
Intestine, Small / secretion
Middle Aged
Pentagastrin / physiology
Secretin / physiology*
Reg. No./Substance:
1393-25-5/Secretin; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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