Document Detail


The role of scaffold proteins in JNK signalling.
MedLine Citation:
PMID:  19922489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper summarises how scaffold proteins affects and regulate the JNK signalling pathway. We believe that some of these scaffold proteins, by virtue of their anchoring and catalytic properties contribute to a high degree of specificity of intra cellular signalling pathways that regulate the progression through the cell cycle.
Authors:
W Engström; A Ward; K Moorwood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-11-17
Journal Detail:
Title:  Cell proliferation     Volume:  43     ISSN:  1365-2184     ISO Abbreviation:  Cell Prolif.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-14     Completed Date:  2010-02-12     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9105195     Medline TA:  Cell Prolif     Country:  England    
Other Details:
Languages:  eng     Pagination:  56-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / genetics,  metabolism,  physiology*
Animals
Apoptosis
JNK Mitogen-Activated Protein Kinases / metabolism*
MAP Kinase Kinase Kinases / metabolism,  physiology
MAP Kinase Signaling System*
Mice
Mice, Knockout
Nerve Tissue Proteins / genetics,  metabolism,  physiology
Saccharomyces cerevisiae Proteins / physiology
Grant Support
ID/Acronym/Agency:
G0300415//Medical Research Council; //Cancer Research UK; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Mapk8ip protein, mouse; 0/Mapk8ip2 protein, mouse; 0/Mapk8ip3 protein, mouse; 0/Nerve Tissue Proteins; 0/STE5 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; 0/Spag9 protein, mouse; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases; EC 2.7.11.25/MAP Kinase Kinase Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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