| The role of routine imaging procedures in the detection of relapse of patients with Hodgkin lymphoma and aggressive non-Hodgkin lymphoma. | |
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MedLine Citation:
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PMID: 20706721 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Despite improved initial therapies, a subgroup of patients with aggressive non-Hodgkin (A-NHL) and Hodgkin lymphomas (HL) will relapse after first remission. The optimal follow-up strategy for the detection of relapse has not been clarified and periodic imaging is not recommended in most written guidelines. We identified 125 patients with HL and A-NHL diagnosed between January 1993 and September 2008 who relapsed at least 1 month after the end of initial therapy. We assessed whether relapse was detected based on clinical signs or periodic computed tomography (CT), [(18)F] fluorodeoxyglucose positron emission tomography (PET), or combined PET/CT and whether the mode of detection influenced the pattern and outcome of relapsed disease. Overall, most relapses (62%) were diagnosed clinically especially in A-NHL and in patients with extranodal involvement at diagnosis (p < 0.05); however, relapses of HL occurring after 2001 when PET/CT became available were more commonly detected by routine imaging (p < 0.05). Imaging-detected relapse was not associated with improved survival. While clinical exam remains the most common mode of detecting relapse, our results suggest a potential role for routine PET/CT surveillance in HL patients; however, survival does not appear to be affected by mode of detection. |
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Authors:
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Neta Goldschmidt; Omer Or; Martine Klein; Bella Savitsky; Ora Paltiel |
Publication Detail:
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Type: Journal Article Date: 2010-08-13 |
Journal Detail:
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Title: Annals of hematology Volume: 90 ISSN: 1432-0584 ISO Abbreviation: Ann. Hematol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: Germany |
Other Details:
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Languages: eng Pagination: 165-71 Citation Subset: IM |
Affiliation:
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Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, neta@hadassah.org.il. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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