| The role of ribose on oxidative stress during hypoxic exercise: a pilot study. | |
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MedLine Citation:
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PMID: 19627222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxygen free radicals are produced during stress, are unstable, and potentially interact with other cellular components or molecules. This reactivity can influence cellular function, including a prolongation in tissue recovery following exercise. We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production during hypoxic exercise. Seven healthy volunteers cycled at their lactate threshold for 25 minutes while inhaling 16% O(2) with a subsequent 60-minute resting period at room air. Subjects ingested either placebo or 7 g of ribose in 250 mL of water before and after the exercise session. Urinary malondialdehyde (MDA) and plasma reduced glutathione levels increased significantly during placebo ingestion (0.2 +/- 0.03 nM/mg and 0.26 +/- 0.29 microM, respectively) but were lower with ribose supplementation (0.04 +/- 0.03 nM/mg and 0.38 +/- 0.29 microM, respectively; P < .05). Uric acid levels were similar between groups (ribose vs. placebo, 4.55 +/- 0.06 mg/dL vs. 4.67 +/- 0.06 mg/dL). Ribose demonstrated a beneficial trend in lower MDA and reduced glutathione levels during hypoxic stress. |
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Authors:
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John G Seifert; Andrew W Subudhi; Min-Xin Fu; Karen L Riska; Jeff C John; Linda M Shecterle; John A St Cyr |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of medicinal food Volume: 12 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-24 Completed Date: 2009-11-30 Revised Date: 2010-05-19 |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 690-3 Citation Subset: IM |
Affiliation:
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Department of Health and Human Development, Montana State University, Bozeman, 59717, USA. john.seifert@montana.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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drug therapy*,
physiopathology* Antioxidants / pharmacology* Bicycling / physiology* Cross-Over Studies Dietary Carbohydrates / metabolism Dietary Supplements Double-Blind Method Exercise / physiology* Free Radicals / metabolism Glutathione / blood* Humans Lactic Acid / metabolism Malondialdehyde / urine* Oxidative Stress* Oxygen / metabolism Pilot Projects Ribose / metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Dietary Carbohydrates; 0/Free Radicals; 50-21-5/Lactic Acid; 50-69-1/Ribose; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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