Document Detail

The role of ribose on oxidative stress during hypoxic exercise: a pilot study.
MedLine Citation:
PMID:  19627222     Owner:  NLM     Status:  MEDLINE    
Oxygen free radicals are produced during stress, are unstable, and potentially interact with other cellular components or molecules. This reactivity can influence cellular function, including a prolongation in tissue recovery following exercise. We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production during hypoxic exercise. Seven healthy volunteers cycled at their lactate threshold for 25 minutes while inhaling 16% O(2) with a subsequent 60-minute resting period at room air. Subjects ingested either placebo or 7 g of ribose in 250 mL of water before and after the exercise session. Urinary malondialdehyde (MDA) and plasma reduced glutathione levels increased significantly during placebo ingestion (0.2 +/- 0.03 nM/mg and 0.26 +/- 0.29 microM, respectively) but were lower with ribose supplementation (0.04 +/- 0.03 nM/mg and 0.38 +/- 0.29 microM, respectively; P < .05). Uric acid levels were similar between groups (ribose vs. placebo, 4.55 +/- 0.06 mg/dL vs. 4.67 +/- 0.06 mg/dL). Ribose demonstrated a beneficial trend in lower MDA and reduced glutathione levels during hypoxic stress.
John G Seifert; Andrew W Subudhi; Min-Xin Fu; Karen L Riska; Jeff C John; Linda M Shecterle; John A St Cyr
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of medicinal food     Volume:  12     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-11-30     Revised Date:  2010-05-19    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  690-3     Citation Subset:  IM    
Department of Health and Human Development, Montana State University, Bozeman, 59717, USA.
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MeSH Terms
Anoxia / drug therapy*,  physiopathology*
Antioxidants / pharmacology*
Bicycling / physiology*
Cross-Over Studies
Dietary Carbohydrates / metabolism
Dietary Supplements
Double-Blind Method
Exercise / physiology*
Free Radicals / metabolism
Glutathione / blood*
Lactic Acid / metabolism
Malondialdehyde / urine*
Oxidative Stress*
Oxygen / metabolism
Pilot Projects
Ribose / metabolism,  physiology*
Reg. No./Substance:
0/Antioxidants; 0/Dietary Carbohydrates; 0/Free Radicals; 50-21-5/Lactic Acid; 50-69-1/Ribose; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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