Document Detail


The role of rhinovirus infections in the development of early childhood asthma.
MedLine Citation:
PMID:  19996738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To discuss the role of human rhinoviruses (HRVs) in early childhood wheezing illnesses and how HRVs contribute to the development of childhood asthma.
RECENT FINDINGS: Advanced molecular diagnostics have identified HRVs as pathogens frequently causing wheezing illnesses in infants and young children. Wheezing during HRV infection in early life identifies children at particularly high-risk of asthma development. Plausible mechanisms by which HRV could cause airway damage, promote airway remodeling, and lead to asthma development have recently been identified.
SUMMARY: HRV is a significant source of morbidity in infants and young children. The present review identifies mechanisms by which HRV lower respiratory tract infection, particularly in a susceptible host, could promote the development of childhood asthma. Further studies are needed to elucidate the mechanisms underlying the link between HRV wheezing in early childhood and subsequent asthma development, with the critical goal of identifying novel therapeutic and prevention strategies for both early childhood wheezing and asthma.
Authors:
Daniel J Jackson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  10     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-09-08     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Asthma / epidemiology*,  etiology,  physiopathology
Child
Child, Preschool
Comorbidity
Humans
Infant
Picornaviridae Infections / complications,  epidemiology*,  physiopathology
Respiratory Sounds
Rhinovirus / immunology*,  pathogenicity
Risk Factors
Grant Support
ID/Acronym/Agency:
P01 HL070831/HL/NHLBI NIH HHS; P01 HL070831-01/HL/NHLBI NIH HHS; P01 HL70831/HL/NHLBI NIH HHS; T32 AI007635/AI/NIAID NIH HHS; T32 AI007635/AI/NIAID NIH HHS; T32 AI007635-10/AI/NIAID NIH HHS
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