| The role of rhinovirus infections in the development of early childhood asthma. | |
| | |
MedLine Citation:
|
PMID: 19996738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: To discuss the role of human rhinoviruses (HRVs) in early childhood wheezing illnesses and how HRVs contribute to the development of childhood asthma. RECENT FINDINGS: Advanced molecular diagnostics have identified HRVs as pathogens frequently causing wheezing illnesses in infants and young children. Wheezing during HRV infection in early life identifies children at particularly high-risk of asthma development. Plausible mechanisms by which HRV could cause airway damage, promote airway remodeling, and lead to asthma development have recently been identified. SUMMARY: HRV is a significant source of morbidity in infants and young children. The present review identifies mechanisms by which HRV lower respiratory tract infection, particularly in a susceptible host, could promote the development of childhood asthma. Further studies are needed to elucidate the mechanisms underlying the link between HRV wheezing in early childhood and subsequent asthma development, with the critical goal of identifying novel therapeutic and prevention strategies for both early childhood wheezing and asthma. |
| | |
Authors:
|
Daniel J Jackson |
Related Documents
:
|
14632328 - High body mass index, asthma and allergy in swedish schoolchildren participating in the... 16166178 - Comparison of complementary and alternative medicine use: reasons and motivations betwe... 21311598 - Added value measures in education show genetic as well as environmental influence. 11411378 - Chronic obstructive pulmonary disease in children. 3916998 - Endodontic treatment for traumatized immature permanent incisors. 11985298 - Effects of social support on children's eyewitness reports: a test of the underlying me... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Current opinion in allergy and clinical immunology Volume: 10 ISSN: 1473-6322 ISO Abbreviation: Curr Opin Allergy Clin Immunol Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-14 Completed Date: 2010-09-08 Revised Date: 2011-05-19 |
Medline Journal Info:
|
Nlm Unique ID: 100936359 Medline TA: Curr Opin Allergy Clin Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
|
University of Wisconsin School of Medicine and Public Health, Department of Pediatrics, Madison, Wisconsin 53792, USA. djj@medicine.wisc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Asthma
/
epidemiology*,
etiology,
physiopathology Child Child, Preschool Comorbidity Humans Infant Picornaviridae Infections / complications, epidemiology*, physiopathology Respiratory Sounds Rhinovirus / immunology*, pathogenicity Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
|
P01 HL070831-01/HL/NHLBI NIH HHS; P01 HL70831/HL/NHLBI NIH HHS; T32 AI007635/AI/NIAID NIH HHS; T32 AI007635-10/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association between plasma asymmetrical dimethylarginine activity and saphenous vein graft disease i...
Next Document: Signaling pathways critical for allergic airway inflammation.