Document Detail


On the role of retrosplenial cortex in long-lasting memory storage.
MedLine Citation:
PMID:  23355414     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time. © 2013 Wiley Periodicals, Inc.
Authors:
Cynthia Katche; Guido Dorman; Carolina Gonzalez; Cecilia P Kramar; Leandro Slipczuk; Janine I Rossato; Martin Cammarota; Jorge H Medina
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Hippocampus     Volume:  -     ISSN:  1098-1063     ISO Abbreviation:  Hippocampus     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Affiliation:
Instituto de Biologia Celular y Neurociencias, Facultad de Medicina, UBA, Paraguay 2155, 3 piso, Buenos Aires 1121ABG, Argentina.
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