Document Detail


The role of retinoic acid in the morphogenesis of the neural tube.
MedLine Citation:
PMID:  14620376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have examined the role of the signalling molecule, retinoic acid, in the process of neurulation and the subsequent growth and differentiation of the central nervous system using quail embryos that have developed in the absence of retinoic acid. Such retinoic acid-free embryos undergo abnormal neural tube formation in terms of its shape and structure, but the embryos do not display spina bifida or exencephaly. The neural tubes have a wider floor plate, a thicker roof plate and a different dorsoventral shape. Phalloidin staining and electron microscopy revealed alterations in the actin filaments and the junctional complexes of the cell layer lining the lumen. Initially the neural tubes proliferated at the same rate as normal, but later the proliferation rate declined drastically and neuronal differentiation was highly deficient. There were very few motoneurons extending neurites into the periphery, and within the neural tube axon trajectories were chaotic. These results reveal several functions for retinoic acid in the morphogenesis and growth of the neural tube, many of which can be explained by defective notochord signalling, but they do not suggest that this molecule plays a role in neural tube closure.
Authors:
L Wilson; E Gale; M Maden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of anatomy     Volume:  203     ISSN:  0021-8782     ISO Abbreviation:  J. Anat.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2003-12-16     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-68     Citation Subset:  IM    
Affiliation:
MRC Centre for Developmental Neurobiology, King's College London, Guy's Campus, London SE1 1UL, UK.
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MeSH Terms
Descriptor/Qualifier:
Actin Cytoskeleton / ultrastructure
Animals
Apoptosis
Cell Division / physiology
Central Nervous System / embryology*,  ultrastructure
In Situ Hybridization
Microscopy, Electron
Models, Animal
Morphogenesis / physiology
Notochord / physiology*
Quail
Signal Transduction / physiology*
Staining and Labeling
Tretinoin / physiology*
Vitamin A Deficiency / embryology*
Chemical
Reg. No./Substance:
302-79-4/Tretinoin
Comments/Corrections

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