Document Detail

The role of repeatedly heated soybean oil in the development of hypertension in rats: association with vascular inflammation.
MedLine Citation:
PMID:  22974219     Owner:  NLM     Status:  MEDLINE    
Thermally oxidized oil generates reactive oxygen species that have been implicated in several pathological processes including hypertension. This study was to ascertain the role of inflammation in the blood pressure raising effect of heated soybean oil in rats. Male Sprague-Dawley rats were divided into four groups and were fed with the following diets, respectively, for 6 months: basal diet (control); fresh soybean oil (FSO); five-time-heated soybean oil (5HSO); or 10-time-heated soybean oil (10HSO). Blood pressure was measured at baseline and monthly using tail-cuff method. Plasma prostacyclin (PGI(2) ) and thromboxane A(2) (TXA(2) ) were measured prior to treatment and at the end of the study. After six months, the rats were sacrificed, and the aortic arches were dissected for morphometric and immunohistochemical analyses. Blood pressure was increased significantly in the 5HSO and 10HSO groups. The blood pressure was maintained throughout the study in rats fed FSO. The aortae in the 5HSO and 10HSO groups showed significantly increased aortic wall thickness, area and circumferential wall tension. 5HSO and 10HSO diets significantly increased plasma TXA(2) /PGI(2) ratio. Endothelial VCAM-1 and ICAM-1 were significantly increased in 5HSO, as well as LOX-1 in 10HSO groups. In conclusion, prolonged consumption of repeatedly heated soybean oil causes blood pressure elevation, which may be attributed to inflammation.
Chun-Yi Ng; Yusof Kamisah; Othman Faizah; Kamsiah Jaarin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of experimental pathology     Volume:  93     ISSN:  1365-2613     ISO Abbreviation:  Int J Exp Pathol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-14     Completed Date:  2012-11-27     Revised Date:  2013-10-09    
Medline Journal Info:
Nlm Unique ID:  9014042     Medline TA:  Int J Exp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-87     Citation Subset:  IM    
Copyright Information:
© 2012 Universiti Kebangsaan Malaysia. International Journal of Experimental Pathology © 2012 International Journal of Experimental Pathology.
Department of Pharmacology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
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MeSH Terms
Aorta, Thoracic / metabolism,  pathology*
Blood Pressure / drug effects*
Heating / adverse effects*
Hypertension / etiology*,  metabolism,  pathology
Inflammation / etiology*,  metabolism,  pathology
Rats, Sprague-Dawley
Reactive Oxygen Species / metabolism
Soybean Oil / adverse effects*,  chemistry
Reg. No./Substance:
0/Reactive Oxygen Species; 8001-22-7/Soybean Oil

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