| The role of renin inhibition in treating the hypertensive patient with diabetes: a summary of preclinical and clinical evidence. | |
| | |
MedLine Citation:
|
PMID: 22292880 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Comorbid hypertension and diabetes is common and associated with substantially greater cardiovascular and renal risk relative to hypertension alone. Tissue renin-angiotensin system (RAS) overactivity is a hallmark of diabetes and contributes to target organ damage. Treatment guidelines recommend angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) for reducing cardiorenal risk in patients with hypertension plus diabetes. However, these agents only partially prevent cardiovascular and renal morbidity/mortality. Further attempts to improve clinical outcomes have focused on the use of an ACE inhibitor plus an ARB, but this combination has not demonstrated a favorable risk-benefit profile. Direct renin inhibitors provide a more comprehensive blockade of the RAS compared with ACE inhibitors or ARBs, and may be of particular benefit in counteracting tissue RAS overactivity. In this article, the role of the RAS in diabetic hypertension and the preclinical and clinical effects of direct renin inhibitor therapy on target organs are reviewed. |
| | |
Authors:
|
Abdul Ali Abdellatif |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Expert review of cardiovascular therapy Volume: 10 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
|
Languages: eng Pagination: 251-63 Citation Subset: IM |
Affiliation:
|
Kidney Hypertension Transplant Clinic, Clear Lake Specialties, Baylor College of Medicine, Houston, TX 77030, USA. abdula@bcm.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Care of patients with acute pulmonary emboli: a clinical review with cardiovascular focus.
Next Document: Concentration dependence of the interfacial tension for aqueous two-phase polymer solutions of dextr...