Document Detail


The role of renin in the antihypertensive action of beta-adrenoreceptor blocking agents.
MedLine Citation:
PMID:  6247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since the original reports suggesting that the antihypertensive action of beta-adrenoreceptor blocking drugs is related to their inhibitory action on renin release, much evidence has been put forward both to refute and support this hypothesis. Our studies of the acute and chronic effects of treatment with propranolol in hypertensive patients showed that the antihypertensive action of the drug was of later onset than the initial cardio-depressant and renin-suppressive effects and had little relationship to the pre-treatment levels of treatment-induced changes in plasma renin activity (PRA). When pindolol was substituted for propranolol in these studies PRA rose, but blood pressure control was undisturbed. Again, in animal experiments, although a range of different beta-adrenoreceptor blocking agents induced decreases in both blood pressure and PRA, the hypotensive effects of pindolol was associated with a rise in PRA. Further, PRA proved to be a poor guide to therapeutic effectiveness in the treatment of an unselected population of hypertensive patients with propranolol. It is concluded that the antihypertensive action of beta-adrenoreceptor blocking agents, as a class, is not dependent upon suppression of PRA.
Authors:
G S Stokes; R M Graham; M A Weber
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Drugs     Volume:  11 SUPPL 1     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1976  
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  150-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology*
Aldosterone / urine
Animals
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects
Clinical Trials as Topic
Depression, Chemical
Humans
Oxprenolol / pharmacology
Pindolol / pharmacology
Propranolol / pharmacology
Rabbits
Renin / blood*,  physiology
Spironolactone / pharmacology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 13523-86-9/Pindolol; 52-01-7/Spironolactone; 52-39-1/Aldosterone; 525-66-6/Propranolol; 6452-71-7/Oxprenolol; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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