Document Detail

The role of the renin-angiotensin system in blood pressure regulation in normotensive animals and man.
MedLine Citation:
PMID:  6100873     Owner:  NLM     Status:  MEDLINE    
The role of the renin-angiotensin system in the control of blood pressure in normal rodents, primates and man has been evaluated using inhibitors which block the system at various stages. Renin plays a major role in the maintenance of blood pressure under volume depletion. In subjects with a normal salt intake, the contribution of the renin-angiotensin system in maintaining blood pressure levels can be evaluated using angiotensin converting enzyme (ACE) inhibitors. The contribution of the renin-angiotensin system can now be evaluated more closely following the development of new substances which block the renin-angiotensinogen reaction. Available data strongly suggest that renin contributes to the maintenance of blood pressure levels in subjects with a normal salt intake, although to a lesser degree than in subjects on a low sodium intake. The renin-angiotensin system plays a role in the regulation of blood pressure levels in normal experimental animals and man--its importance depending on the state of sodium balance.
P Corvol; J B Michel; G Evin; J Gardes; A Bensala-Alaoui; J Ménard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  2     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1987-02-04     Completed Date:  1987-02-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S25-30     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / antagonists & inhibitors
Blood Pressure* / drug effects
Blood Volume
Captopril / pharmacology
Enalapril / pharmacology
Rats, Inbred Strains
Renin / antagonists & inhibitors,  physiology*
Renin-Angiotensin System* / drug effects
Sodium / physiology
Reg. No./Substance:
11128-99-7/Angiotensin II; 62571-86-2/Captopril; 7440-23-5/Sodium; 75847-73-3/Enalapril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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