Document Detail


A role for the renin-angiotensin system in the evolution of cardiac memory.
MedLine Citation:
PMID:  10355696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: We studied the role of the cardiac renin-angiotensin II system in the genesis of cardiac memory, in which T wave changes induced by ventricular pacing (VP) accumulate and persist during subsequent sinus rhythm. METHODS AND RESULTS: Anesthetized dogs were instrumented via a thoracotomy and three 20-minute runs of VP were interspersed with periods of normal sinus rhythm sufficient to permit T wave recovery to 90% of control. Memory was quantified as the change (delta) in T wave vector angle showing accumulation over the three monitoring periods. In five control dogs T wave vector = -27 +/- 49 degrees, and this shifted by 104 degrees (P < 0.05) over the three postpacing recovery periods. In seven dogs infused with the receptor blocker saralasin, five infused with the angiotensin-converting enzyme inhibitor captopril, and four infused with the tissue protease inhibitor chymostatin, there were significant reductions in the incidence and the accumulation of memory. In four other experiments, we used isolated, blood-perfused canine hearts to demonstrate that VP used to induce memory alters the contractile pattern of the left ventricle. CONCLUSIONS: We propose that the alteration in myocardial stretch induced by pacing activates angiotensin II synthesis by cardiac cells. We propose, further that the endogenous cardiac renin-angiotensin II system (blocked by saralasin, captopril and by chymostatin) is an important contributor to the induction of memory.
Authors:
P Ricard; P Danilo; I S Cohen; D Burkhoff; M R Rosen
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  10     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-15     Completed Date:  1999-07-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  545-51     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / biosynthesis
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Animals
Captopril / pharmacology
Dogs
Electric Stimulation
Electrocardiography
Female
Heart Conduction System / drug effects,  physiology*
Male
Myocardial Contraction / drug effects
Myocardium / metabolism*
Oligopeptides / pharmacology
Perfusion
Renin-Angiotensin System / drug effects,  physiology*
Saralasin / pharmacology
Serine Proteinase Inhibitors / pharmacology
Grant Support
ID/Acronym/Agency:
HL-28958/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Oligopeptides; 0/Serine Proteinase Inhibitors; 11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 62571-86-2/Captopril; 9076-44-2/chymostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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