| A role for the renin-angiotensin system in the evolution of cardiac memory. | |
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MedLine Citation:
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PMID: 10355696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: We studied the role of the cardiac renin-angiotensin II system in the genesis of cardiac memory, in which T wave changes induced by ventricular pacing (VP) accumulate and persist during subsequent sinus rhythm. METHODS AND RESULTS: Anesthetized dogs were instrumented via a thoracotomy and three 20-minute runs of VP were interspersed with periods of normal sinus rhythm sufficient to permit T wave recovery to 90% of control. Memory was quantified as the change (delta) in T wave vector angle showing accumulation over the three monitoring periods. In five control dogs T wave vector = -27 +/- 49 degrees, and this shifted by 104 degrees (P < 0.05) over the three postpacing recovery periods. In seven dogs infused with the receptor blocker saralasin, five infused with the angiotensin-converting enzyme inhibitor captopril, and four infused with the tissue protease inhibitor chymostatin, there were significant reductions in the incidence and the accumulation of memory. In four other experiments, we used isolated, blood-perfused canine hearts to demonstrate that VP used to induce memory alters the contractile pattern of the left ventricle. CONCLUSIONS: We propose that the alteration in myocardial stretch induced by pacing activates angiotensin II synthesis by cardiac cells. We propose, further that the endogenous cardiac renin-angiotensin II system (blocked by saralasin, captopril and by chymostatin) is an important contributor to the induction of memory. |
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Authors:
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P Ricard; P Danilo; I S Cohen; D Burkhoff; M R Rosen |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of cardiovascular electrophysiology Volume: 10 ISSN: 1045-3873 ISO Abbreviation: J. Cardiovasc. Electrophysiol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-07-15 Completed Date: 1999-07-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 545-51 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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biosynthesis Angiotensin-Converting Enzyme Inhibitors / pharmacology Animals Captopril / pharmacology Dogs Electric Stimulation Electrocardiography Female Heart Conduction System / drug effects, physiology* Male Myocardial Contraction / drug effects Myocardium / metabolism* Oligopeptides / pharmacology Perfusion Renin-Angiotensin System / drug effects, physiology* Saralasin / pharmacology Serine Proteinase Inhibitors / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL-28958/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Oligopeptides; 0/Serine Proteinase Inhibitors; 11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 62571-86-2/Captopril; 9076-44-2/chymostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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