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The role of renal "work" in compensatory kidney growth.
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MedLine Citation:
PMID:  366925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a series of studies designed to test the role of renal "work" in compensatory kidney growth we examined the relationship between absolute sodium reabsorption-which constitutes the bulk of renal energy expenditure, and growth of the remaining kidney at various intervals after contralateral nephrectomy.The increase in weight of the remaining kidney preceded the rise in sodium reabsorption and these two processes took place at different rates between 24 hours and 21 days after uninephrectomy.Absolute sodium reabsorption did not change during the first hours after contralateral nephrectomy, at a time when biochemical alterations are known to occur.The rate of [(14)C] choline incorporation into renal phospholipid, an early biochemical indicator of compensatory kidney growth, increased significantly one hour after contralateral nephrectomy but remained unchanged after sham-nephrectomy, regardless of the magnitude or direction of the concomitant change in absolute sodium reabsorption ("kidney work").These results indicate that renal work expended in the reabsorption of glomerular filtrate is neither the initiating, nor the primary controlling factor, of the compensatory kidney growth that follows unilateral nephrectomy.
Authors:
A I Katz; F G Toback; M D Lindheimer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Yale journal of biology and medicine     Volume:  51     ISSN:  0044-0086     ISO Abbreviation:  Yale J Biol Med     Publication Date:    1978 May-Jun
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2012-05-30    
Medline Journal Info:
Nlm Unique ID:  0417414     Medline TA:  Yale J Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Glomerular Filtration Rate
Hypertrophy
Kidney / pathology,  physiology*
Kidney Tubules, Proximal / metabolism*
Organ Size
Phospholipids / biosynthesis
Proteins / metabolism
RNA / metabolism
Rats
Sodium / metabolism*
Chemical
Reg. No./Substance:
0/Phospholipids; 0/Proteins; 63231-63-0/RNA; 7440-23-5/Sodium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Yale J Biol Med
ISSN: 0044-0086
ISSN: 1551-4056
Article Information
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Print publication date: Season: May?Jun Year: 1978
Volume: 51 Issue: 3
First Page: 331 Last Page: 337
ID: 2595748
PubMed Id: 366925
PubMed Id: 366925

The Role of Renal ?Work? in Compensatory Kidney Growth
Adrian I. Katz
F. Gary Toback
M.D. Lindheimer



Article Categories:
  • Article
Series: Long-Term Responses to Loss of Renal Mass: Control Mechanisms.


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