Document Detail

The role of renal natriuretic and depressor systems in insulin-resistant hypertensive rats.
MedLine Citation:
PMID:  15302987     Owner:  NLM     Status:  MEDLINE    
Insulin resistance and impairment of the renal depressor system have been thought to be involved in the development of essential hypertension. However, the relationship between insulin resistance and this system is still unclear. To clarify this relationship, we investigated the role of the renal depressor system in a rat model of insulin-resistant hypertension. Sprague-Dawley rats were fed a standard diet (control) or a fructose-rich diet (FFR), and their blood pressures were measured every week. Urinary dopamine (uDA), urinary kallikrein (uKAL) activity and urinary nitric oxide (uNOx) levels were also measured each week, and the renal mRNA expression levels of endothelial nitric oxide synthase (eNOS), aromatic-L-amino-acid decarboxylase (AADC), and kallikrein (KAL) activity were compared at the end of the study. The blood pressure of FFR was elevated significantly from 2 weeks after the start of fructose loading. The uDA level was lower in FFR than in control rats throughout the study period (p<0.01), and the expression level of AADC mRNA was enhanced in FFR (p<0.05). There was a tendency of negative correlation between uDA level and systolic blood pressure (SBP) (r=-0.49, p=0.056). uNOx level was lower in FFR throughout the study period (p<0.05), and the eNOS mRNA expression level in the kidney was lower in FFR than in control rats (p<0.05). There was a negative correlation between uNOx level and SBP (r=-0.68, p <0.01). On the other hand, there was no significant difference in the kallikrein-kinin system between FFR and control rats. In conclusion, impairment in functions of the renal dopamine and NO systems occur in FFR, and this impairment may be caused by insulin resistance and may contribute to the development of hypertension.
Koichi Hasegawa; Hideaki Yoshida; Nobuyuki Ura; Hideyuki Murakami; Makoto Hagiwara; Kazuaki Shimamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  27     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-10     Completed Date:  2005-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  501-8     Citation Subset:  IM    
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
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MeSH Terms
Dopamine / urine*
Hypertension / physiopathology*,  urine
Insulin Resistance*
Kallikreins / urine*
Kidney / metabolism*
Nitrates / urine*
Nitrites / urine*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Nitrates; 0/Nitrites; EC 3.4.21.-/Kallikreins

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